Nalbuphine's Hemodynamic Impact in Ear, Nose, and Throat (ENT) Surgeries: A Comprehensive Review

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2024 Feb 23

PMID 38389632

Authors

Dhruv Shah

Jayashree Sen

Affiliations

Soon will be listed here.

Abstract

Nalbuphine, a semi-synthetic opioid, has gained attention for its analgesic properties, but its specific impact on hemodynamics in ear, nose, and throat (ENT) surgeries remains a subject of exploration. This comprehensive review aims to systematically analyze existing literature to understand the nuanced hemodynamic effects of nalbuphine during ENT procedures. Nalbuphine demonstrates promise as an analgesic agent in ENT surgeries with generally stable hemodynamic profiles. However, the variability in study designs and outcomes necessitates a cautious interpretation. The review underscores the need for standardized protocols and further research to elucidate patient-specific considerations, ensuring optimal utilization of nalbuphine in enhancing overall perioperative care for ENT patients.

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References

Nair A, Dudhedia U, Rangaiah M, Panchawagh S . Efficacy of intravenous nalbuphine for managing post-anaesthesia shivering: A systematic review and meta-analysis of randomised controlled trials with trial sequential analysis. Indian J Anaesth. 2023; 67(10):853-865. PMC: 10691608. DOI: 10.4103/ija.ija_482_23. View

Minai F, Khan F . A comparison of morphine and nalbuphine for intraoperative and postoperative analgesia. J Pak Med Assoc. 2003; 53(9):391-6. View

Errick J, Heel R . Nalbuphine. A preliminary review of its pharmacological properties and therapeutic efficacy. Drugs. 1983; 26(3):191-211. DOI: 10.2165/00003495-198326030-00002. View

Zielinski J, Morawska-Kochman M, Dudek K, Czapla M, Zatonski T . The Effect of Pre-Emptive Analgesia on the Postoperative Pain in Pediatric Otolaryngology: A Randomized, Controlled Trial. J Clin Med. 2022; 11(10). PMC: 9146866. DOI: 10.3390/jcm11102713. View

Borgeat A, Fuchs T, Wilder-Smith O, Tassonyi E . The effect of nalbuphine and droperidol on spontaneous movements during induction of anesthesia with propofol in children. J Clin Anesth. 1993; 5(1):12-5. DOI: 10.1016/0952-8180(93)90081-o. View

Verma R, Verma R, Verma R . Tonsillectomy-Comparative Study of Various Techniques and Changing Trend. Indian J Otolaryngol Head Neck Surg. 2017; 69(4):549-558. PMC: 5714902. DOI: 10.1007/s12070-017-1190-6. View

Milonski J, Zielinska-Blizniewska H, Golusinski W, Urbaniak J, Sobanski R, Olszewski J . Effects of three different types of anaesthesia on perioperative bleeding control in functional endoscopic sinus surgery. Eur Arch Otorhinolaryngol. 2012; 270(7):2045-50. PMC: 3669505. DOI: 10.1007/s00405-012-2311-1. View

Pasternak G, Pan Y . Mu opioids and their receptors: evolution of a concept. Pharmacol Rev. 2013; 65(4):1257-317. PMC: 3799236. DOI: 10.1124/pr.112.007138. View

Lee G, Low R, Amsterdam E, DeMaria A, Huber P, Mason D . Hemodynamic effects of morphine and nalbuphine in acute myocardial infarction. Clin Pharmacol Ther. 1981; 29(5):576-81. DOI: 10.1038/clpt.1981.80. View

10.

Sadafule N, Karhade S . Comparative Study of Efficacy of Preoperative Nalbuphine Hydrochloride and Pentazocine Lactate on Hemodynamic Response to Tracheal Intubation and Postoperative Analgesia. Anesth Essays Res. 2018; 12(1):218-222. PMC: 5872867. DOI: 10.4103/aer.AER_168_17. View

11.

Tierney W, Chota R, Benninger M, Nowacki A, Bryson P . Hemodynamic Parameters during Laryngoscopic Procedures in the Office and in the Operating Room. Otolaryngol Head Neck Surg. 2016; 155(3):466-72. DOI: 10.1177/0194599816645809. View

12.

Liu X, Hu J, Hu X, Li R, Li Y, Wong G . Preemptive Intravenous Nalbuphine for the Treatment of Post-Operative Visceral Pain: A Multicenter, Double-Blind, Placebo-Controlled, Randomized Clinical Trial. Pain Ther. 2021; 10(2):1155-1169. PMC: 8586116. DOI: 10.1007/s40122-021-00275-8. View

13.

Chang R, Hussain M . Improvement of nalbuphine bioavailability through rectal administration of a prodrug. Pharm Dev Technol. 1998; 3(1):131-4. DOI: 10.3109/10837459809028487. View

14.

Abebe M, Arefayne N, Temesgen M, Admass B . Incidence and predictive factors associated with hemodynamic instability among adult surgical patients in the post-anesthesia care unit, 2021: A prospective follow up study. Ann Med Surg (Lond). 2022; 74:103321. PMC: 8818524. DOI: 10.1016/j.amsu.2022.103321. View

15.

van den Berg A, Montoya-Pelaez L, Halliday E, Hassan I, Baloch M . Analgesia for adenotonsillectomy in children and young adults: a comparison of tramadol, pethidine and nalbuphine. Eur J Anaesthesiol. 1999; 16(3):186-94. DOI: 10.1046/j.1365-2346.1999.00451.x. View

16.

van den Berg A, Halliday E, Soomro N, Rasheed A, Baloch M . Reducing cardiovascular responses to laryngoscopy and tracheal intubation: a comparison of equipotent doses of tramadol, nalbuphine and pethidine, with placebo. Middle East J Anaesthesiol. 2005; 17(6):1023-36. View

17.

Schnabel A, Reichl S, Zahn P, Pogatzki-Zahn E . Nalbuphine for postoperative pain treatment in children. Cochrane Database Syst Rev. 2014; (7):CD009583. PMC: 10403789. DOI: 10.1002/14651858.CD009583.pub2. View

18.

Smith J, Correll J, Stucken C, Stucken E . Ear, Nose, and Throat Surgery: Postoperative Complications After Selected Head and Neck Operations. Surg Clin North Am. 2021; 101(5):831-844. DOI: 10.1016/j.suc.2021.06.010. View

19.

Oltman J, Militsakh O, DAgostino M, Kauffman B, Lindau R, Coughlin A . Multimodal Analgesia in Outpatient Head and Neck Surgery: A Feasibility and Safety Study. JAMA Otolaryngol Head Neck Surg. 2017; 143(12):1207-1212. PMC: 5824296. DOI: 10.1001/jamaoto.2017.1773. View

20.

Sahu B, Nayak L, Mohapatra P, Mishra K . Induced Hypotension in Functional Endoscopic Sinus Surgery: A Comparative Study of Dexmedetomidine and Esmolol. Cureus. 2021; 13(5):e15069. PMC: 8207487. DOI: 10.7759/cureus.15069. View