Pulmonary Salivary Gland Tumor-hyalinizing Clear Cell Carcinoma: a Literature Review

Overview

Journal Diagn Pathol

Publisher Biomed Central

Specialty Pathology

Date 2024 Feb 23

PMID 38389101

Authors

Xinyuan Wang

Shumin Hu

Hongyang Lu

Affiliations

Soon will be listed here.

Abstract

Primary pulmonary hyalinizing clear cell carcinoma (HCCC) is a very rare lung tumor that accounts for less than 0.09% of all primary lung tumors and has no specific epidemiology. The correct diagnosis requires imaging, laboratory, pathological, immunohistochemical, and molecular examination. The most typical feature of pulmonary HCCC is the clear cell component with clear stroma. In addition, the fusion gene EWSR1::ATF1 due to t(12;22)(q13;q12) is essential for the pathological diagnosis of pulmonary HCCC. The main treatment for pulmonary HCCC is surgery. This review focus on the pathological features, immunohistochemical examination, mutation analysis and treatment of pulmonary HCCC.

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