Durable CD4 T Cell Immunity: Cherchez La Stem

Overview

Journal Trends Immunol

Specialty Allergy & Immunology

Date 2024 Feb 22

PMID 38388231

Authors

Erik P Hughes

Amber R Syage

Dean Tantin

Affiliations

Soon will be listed here.

Abstract

Mammalian stem cells govern development, tissue homeostasis, and regeneration. Following years of study, their functions have been delineated with increasing precision. The past decade has witnessed heightened widespread use of stem cell terminology in association with durable T cell responses to infection, antitumor immunity, and autoimmunity. Interpreting this literature is complicated by the fact that descriptions are diverse and criteria for labeling 'stem-like' T cells are evolving. Working under the hypothesis that conceptual frameworks developed for actual stem cells can be used to better evaluate and organize T cells described to have stem-like features, we outline widely accepted properties of stem cells and compare these to different 'stem-like' CD4 T cell populations.

References

Kondo T, Morita R, Okuzono Y, Nakatsukasa H, Sekiya T, Chikuma S . Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy. Nat Commun. 2017; 8:15338. PMC: 5458121. DOI: 10.1038/ncomms15338. View

Hoechst B, Gamrekelashvili J, Manns M, Greten T, Korangy F . Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells. Blood. 2011; 117(24):6532-41. DOI: 10.1182/blood-2010-11-317321. View

Hosokawa K, Muranski P, Feng X, Townsley D, Liu B, Knickelbein J . Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia. J Immunol. 2016; 196(4):1568-78. PMC: 4744506. DOI: 10.4049/jimmunol.1501739. View

Takeshita M, Suzuki K, Kondo Y, Morita R, Okuzono Y, Koga K . Multi-dimensional analysis identified rheumatoid arthritis-driving pathway in human T cell. Ann Rheum Dis. 2019; 78(10):1346-1356. PMC: 6788883. DOI: 10.1136/annrheumdis-2018-214885. View

Oguro H, Ding L, Morrison S . SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors. Cell Stem Cell. 2013; 13(1):102-16. PMC: 3736853. DOI: 10.1016/j.stem.2013.05.014. View

Bankaitis E, Ha A, Kuo C, Magness S . Reserve Stem Cells in Intestinal Homeostasis and Injury. Gastroenterology. 2018; 155(5):1348-1361. PMC: 7493459. DOI: 10.1053/j.gastro.2018.08.016. View

Fazeli P, Talepoor A, Faghih Z, Gholijani N, Ataollahi M, Ali-Hassanzadeh M . The frequency of CD4+ and CD8+ circulating T stem cell memory in type 1 diabetes. Immun Inflamm Dis. 2022; 10(10):e715. PMC: 9500591. DOI: 10.1002/iid3.715. View

Fung H, Teryek M, Lemenze A, Bergsbaken T . CD103 fate mapping reveals that intestinal CD103 tissue-resident memory T cells are the primary responders to secondary infection. Sci Immunol. 2022; 7(77):eabl9925. PMC: 9901738. DOI: 10.1126/sciimmunol.abl9925. View

Pan Y, Yang W, Tang B, Wang X, Zhang Q, Li W . The protective and pathogenic role of Th17 cell plasticity and function in the tumor microenvironment. Front Immunol. 2023; 14:1192303. PMC: 10339829. DOI: 10.3389/fimmu.2023.1192303. View

10.

Behr F, Parga-Vidal L, Kragten N, van Dam T, Wesselink T, Sheridan B . Tissue-resident memory CD8 T cells shape local and systemic secondary T cell responses. Nat Immunol. 2020; 21(9):1070-1081. DOI: 10.1038/s41590-020-0723-4. View

11.

Takeshita M, Suzuki K, Kassai Y, Takiguchi M, Nakayama Y, Otomo Y . Polarization diversity of human CD4+ stem cell memory T cells. Clin Immunol. 2015; 159(1):107-17. DOI: 10.1016/j.clim.2015.04.010. View

12.

Chen J, Miyanishi M, Wang S, Yamazaki S, Sinha R, Kao K . Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche. Nature. 2016; 530(7589):223-7. PMC: 4854608. DOI: 10.1038/nature16943. View

13.

Wijeyesinghe S, Beura L, Pierson M, Stolley J, Adam O, Ruscher R . Expansible residence decentralizes immune homeostasis. Nature. 2021; 592(7854):457-462. PMC: 8057530. DOI: 10.1038/s41586-021-03351-3. View

14.

Lee Y, Park J, Kwon H, Choi Y, Jung K, Park S . Role of Stem Cell-Like Memory T Cells in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2018; 70(9):1459-1469. DOI: 10.1002/art.40524. View

15.

Nagai Y, Kawahara M, Hishizawa M, Shimazu Y, Sugino N, Fujii S . T memory stem cells are the hierarchical apex of adult T-cell leukemia. Blood. 2015; 125(23):3527-35. DOI: 10.1182/blood-2014-10-607465. View

16.

Spangrude G, Aihara Y, Weissman I, Klein J . The stem cell antigens Sca-1 and Sca-2 subdivide thymic and peripheral T lymphocytes into unique subsets. J Immunol. 1988; 141(11):3697-707. View

17.

Gounari F, Khazaie K . TCF-1: a maverick in T cell development and function. Nat Immunol. 2022; 23(5):671-678. PMC: 9202512. DOI: 10.1038/s41590-022-01194-2. View

18.

Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A . Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999; 401(6754):708-12. DOI: 10.1038/44385. View

19.

Ayyaz A, Kumar S, Sangiorgi B, Ghoshal B, Gosio J, Ouladan S . Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell. Nature. 2019; 569(7754):121-125. DOI: 10.1038/s41586-019-1154-y. View

20.

Costa Del Amo P, Lahoz-Beneytez J, Boelen L, Ahmed R, Miners K, Zhang Y . Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness. PLoS Biol. 2018; 16(6):e2005523. PMC: 6033534. DOI: 10.1371/journal.pbio.2005523. View