Metabolic Basis of Cardiac Dysfunction in Cancer Patients

Overview

Journal Curr Opin Cardiol

Specialty Cardiology & Vascular Diseases

Date 2024 Feb 22

PMID 38386340

Authors

Jane C Figueiredo

Neil Adri Bhowmick

Anja Karlstaedt

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: The relationship between metabolism and cardiovascular diseases is complex and bidirectional. Cardiac cells must adapt metabolic pathways to meet biosynthetic demands and energy requirements to maintain contractile function. During cancer, this homeostasis is challenged by the increased metabolic demands of proliferating cancer cells.

Recent Findings: Tumors have a systemic metabolic impact that extends beyond the tumor microenvironment. Lipid metabolism is critical to cancer cell proliferation, metabolic adaptation, and increased cardiovascular risk. Metabolites serve as signals which provide insights for diagnosis and prognosis in cardio-oncology patients.

Summary: Metabolic processes demonstrate a complex relationship between cancer cell states and cardiovascular remodeling with potential for therapeutic interventions.

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