PPM1G Promotes Cell Proliferation Via Modulating Mutant GOF P53 Protein Expression in Hepatocellular Carcinoma

Overview

Journal iScience

Publisher Cell Press

Date 2024 Feb 22

PMID 38384839

Authors

Wen Hu

Shao-Lin Ma

Liang Qiong

Yu Du

Li-Ping Gong

Yu-Hang Pan

Li-Ping Sun

Jing-Yun Wen

Jian-Ning Chen

Xin-Yuan Guan

Chun-Kui Shao

Affiliations

Soon will be listed here.

Abstract

The serine/threonine protein phosphatase family involves series of cellular processes, such as pre-mRNA splicing. The function of one of its members, protein phosphatase, Mg/Mn2+ dependent 1G (PPM1G), remains unclear in hepatocellular carcinoma (HCC). Our results demonstrated that PPM1G was significantly overexpressed in HCC cells and tumor tissues compared with the normal liver tissues at both protein and RNA levels. High PPM1G expression is associated with shorter overall survival (p < 0.0001) and disease-free survival (p = 0.004) in HCC patients. Enhanced expression of PPM1G increases the cell proliferation rate, and knockdown of PPM1G led to a significant reduction in tumor volume . Further experiments illustrated that upregulated-PPM1G expression increased the protein expression of gain-of-function (GOF) mutant p53. Besides, the immunoprecipitation analysis revealed a direct interaction between PPM1G and GOF mutant p53. Collectively, PPM1G can be a powerful prognostic predictor and potential drug-target molecule.

Citing Articles

PPM1G and its diagnostic, prognostic and therapeutic potential in HCC (Review).

Zhang X, Wang H, Yuan Y, Zhang J, Yang J, Zhang L Int J Oncol. 2024; 65(5).

PMID: 39329206 PMC: 11436262. DOI: 10.3892/ijo.2024.5697.

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