Metabolomic Biomarkers in Liquid Biopsy: Accurate Cancer Diagnosis and Prognosis Monitoring

Overview

Journal Front Oncol

Specialty Oncology

Date 2024 Feb 22

PMID 38384814

Authors

Wenqian Wang

Shanshan Zhen

Yu Ping

Liping Wang

Yi Zhang

Affiliations

Soon will be listed here.

Abstract

Liquid biopsy, a novel detection method, has recently become an active research area in clinical cancer owing to its unique advantages. Studies on circulating free DNA, circulating tumor cells, and exosomes obtained by liquid biopsy have shown great advances and they have entered clinical practice as new cancer biomarkers. The metabolism of the body is dynamic as cancer originates and progresses. Metabolic abnormalities caused by cancer can be detected in the blood, sputum, urine, and other biological fluids via systemic or local circulation. A considerable number of recent studies have focused on the roles of metabolic molecules in cancer. The purpose of this review is to provide an overview of metabolic markers from various biological fluids in the latest clinical studies, which may contribute to cancer screening and diagnosis, differentiation of cancer typing, grading and staging, and prediction of therapeutic response and prognosis.

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