Skin and Hard Surface Disinfection Against - What We Know Today

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2024 Feb 22

PMID 38384416

Authors

Soraya Omardien

Peter Teska

Affiliations

Soon will be listed here.

Abstract

has emerged as a global healthcare threat, displaying resistance to important healthcare antifungal therapies. Infection prevention and control protocols have become paramount in reducing transmission of in healthcare, of which cleaning and disinfection plays an important role. is used as a surrogate yeast for yeasticidal claims of disinfection products, but reports have been made that sensitivity to disinfectants by differs from its surrogate. In this review, we aimed to compile the information reported for products used for skin and hard surface disinfection against in its planktonic or biofilm form. A comparison was made with other species, and information were gathered from laboratory studies and observations made in healthcare settings.

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References

Voorn M, Kelley A, Chaggar G, Li X, Teska P, Oliver H . Contact time and disinfectant formulation significantly impact the efficacies of disinfectant towelettes against Candida auris on hard, non-porous surfaces. Sci Rep. 2023; 13(1):5849. PMC: 10086017. DOI: 10.1038/s41598-023-32876-y. View

Jones I, Joshi L . Biocide Use in the Antimicrobial Era: A Review. Molecules. 2021; 26(8). PMC: 8071000. DOI: 10.3390/molecules26082276. View

Almatroudi A, Gosbell I, Hu H, Jensen S, Espedido B, Tahir S . Staphylococcus aureus dry-surface biofilms are not killed by sodium hypochlorite: implications for infection control. J Hosp Infect. 2016; 93(3):263-70. DOI: 10.1016/j.jhin.2016.03.020. View

Satoh K, Makimura K, Hasumi Y, Nishiyama Y, Uchida K, Yamaguchi H . Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital. Microbiol Immunol. 2009; 53(1):41-4. DOI: 10.1111/j.1348-0421.2008.00083.x. View

Forgacs L, Borman A, Prepost E, Toth Z, Kardos G, Kovacs R . Comparison of pathogenicity of four clades in a neutropenic bloodstream infection murine model. Emerg Microbes Infect. 2020; 9(1):1160-1169. PMC: 7448943. DOI: 10.1080/22221751.2020.1771218. View

Rajendran R, Sherry L, Nile C, Sherriff A, Johnson E, Hanson M . Biofilm formation is a risk factor for mortality in patients with Candida albicans bloodstream infection-Scotland, 2012-2013. Clin Microbiol Infect. 2015; 22(1):87-93. PMC: 4721535. DOI: 10.1016/j.cmi.2015.09.018. View

Eyre D, Sheppard A, Madder H, Moir I, Moroney R, Quan T . A Candida auris Outbreak and Its Control in an Intensive Care Setting. N Engl J Med. 2018; 379(14):1322-1331. DOI: 10.1056/NEJMoa1714373. View

Borman A, Fraser M, Johnson E . CHROMagarTM Candida Plus: A novel chromogenic agar that permits the rapid identification of Candida auris. Med Mycol. 2020; 59(3):253-258. DOI: 10.1093/mmy/myaa049. View

Rossato L, Colombo A . What Have We Learned About Its Mechanisms of Pathogenicity?. Front Microbiol. 2019; 9:3081. PMC: 6315175. DOI: 10.3389/fmicb.2018.03081. View

10.

Lockhart S, Etienne K, Vallabhaneni S, Farooqi J, Chowdhary A, Govender N . Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses. Clin Infect Dis. 2016; 64(2):134-140. PMC: 5215215. DOI: 10.1093/cid/ciw691. View

11.

Kuhbacher A, Burger-Kentischer A, Rupp S . Interaction of Candida Species with the Skin. Microorganisms. 2017; 5(2). PMC: 5488103. DOI: 10.3390/microorganisms5020032. View

12.

Borman A, Szekely A, Johnson E . Comparative Pathogenicity of United Kingdom Isolates of the Emerging Pathogen Candida auris and Other Key Pathogenic Candida Species. mSphere. 2016; 1(4). PMC: 4990711. DOI: 10.1128/mSphere.00189-16. View

13.

Piedrahita C, Cadnum J, Jencson A, Shaikh A, Ghannoum M, Donskey C . Environmental Surfaces in Healthcare Facilities are a Potential Source for Transmission of Candida auris and Other Candida Species. Infect Control Hosp Epidemiol. 2017; 38(9):1107-1109. DOI: 10.1017/ice.2017.127. View

14.

Caceres D, Forsberg K, Welsh R, Sexton D, Lockhart S, Jackson B . : A Review of Recommendations for Detection and Control in Healthcare Settings. J Fungi (Basel). 2019; 5(4). PMC: 6958335. DOI: 10.3390/jof5040111. View

15.

Lee W, Shin J, Uh Y, Kang M, Kim S, Park K . First three reported cases of nosocomial fungemia caused by Candida auris. J Clin Microbiol. 2011; 49(9):3139-42. PMC: 3165631. DOI: 10.1128/JCM.00319-11. View

16.

Larkin E, Hager C, Chandra J, Mukherjee P, Retuerto M, Salem I . The Emerging Pathogen Candida auris: Growth Phenotype, Virulence Factors, Activity of Antifungals, and Effect of SCY-078, a Novel Glucan Synthesis Inhibitor, on Growth Morphology and Biofilm Formation. Antimicrob Agents Chemother. 2017; 61(5). PMC: 5404565. DOI: 10.1128/AAC.02396-16. View

17.

Fortun J, Martin-Davila P, Gomez-Garcia de la Pedrosa E, Pintado V, Cobo J, Fresco G . Emerging trends in candidemia: a higher incidence but a similar outcome. J Infect. 2012; 65(1):64-70. DOI: 10.1016/j.jinf.2012.02.011. View

18.

Schelenz S, Hagen F, Rhodes J, Abdolrasouli A, Chowdhary A, Hall A . First hospital outbreak of the globally emerging in a European hospital. Antimicrob Resist Infect Control. 2016; 5:35. PMC: 5069812. DOI: 10.1186/s13756-016-0132-5. View

19.

Muller P, Tan C, Issleib U, Passvogel L, Eilts B, Steinhauer K . Investigation of the susceptibility of Candida auris and Candida albicans to chemical disinfectants using European Standards EN 13624 and EN 16615. J Hosp Infect. 2020; 105(4):648-656. DOI: 10.1016/j.jhin.2020.05.026. View

20.

Sears D, Schwartz B . Candida auris: An emerging multidrug-resistant pathogen. Int J Infect Dis. 2017; 63:95-98. DOI: 10.1016/j.ijid.2017.08.017. View