Nuclear Actin Filaments - a Historical Perspective

Overview

Journal Nucleus

Date 2024 Feb 22

PMID 38384139

Authors

Maria Kristha Fernandez

Molika Sinha

Mia Zidan

Malte Renz

Affiliations

Soon will be listed here.

Abstract

The view on nuclear filaments formed by non-skeletal β-actin has significantly changed over the decades. Initially, filamentous actin was observed in amphibian oocyte nuclei and only under specific cell stress conditions in mammalian cell nuclei. Improved labeling and imaging technologies have permitted insights into a transient but microscopically apparent filament network that is relevant for chromatin organization, biomechanics of the mammalian cell nucleus, gene expression, and DNA damage repair. Here, we will provide a historical perspective on the developing insight into nuclear actin filaments.

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