Efficacy of Mesenchymal Stromal Cells in the Treatment of Type 1 Diabetes: a Systematic Review

Overview

Journal Cell Tissue Bank

Specialties Anatomy & Histology
Cell Biology
General Surgery

Date 2024 Feb 22

PMID 38383908

Authors

Jiaxin Liu

Yang Yang

Yun Qi

Affiliations

Soon will be listed here.

Abstract

To investigate the efficacy of mesenchymal stromal cells in the treatment of type 1 diabetes. Articles about the effects of mesenchymal stromal cells for T1D were retrieved in PubMed, Web of Science, Embase, and the Cochrane Library databases up to July 2023. Additional relevant studies were manually searched through citations. HbA1c, FBG, PBG, insulin requirement and C-peptide were assessed. The risk of bias was evaluated with the ROB 2.0 and ROBINS-I tools. Six RCTs and eight nRCTs were included. Of the 14 studies included, two evaluated BM-MSCs, three evaluated UC-MSCs, five evaluated AHSCT, two evaluated CB-SCs, and two evaluated UC-SCs plus aBM-MNCs. At the end of follow-up, ten studies found that mesenchymal stromal cells improved glycemic outcomes in T1D, while the remaining four studies showed no significant improvement. Findings support the positive impacts observed from utilizing mesenchymal stromal cells in individuals with T1D. However, the overall methodological quality of the identified studies and findings is heterogeneous, limiting the interpretation of the therapeutic benefits of mesenchymal stromal cells in T1D. Methodically rigorous research is needed to further increase credibility.

Citing Articles

Human mesenchymal stem/stromal cell based-therapy in diabetes mellitus: experimental and clinical perspectives.

Zeinhom A, Fadallah S, Mahmoud M Stem Cell Res Ther. 2024; 15(1):384.

PMID: 39468609 PMC: 11520428. DOI: 10.1186/s13287-024-03974-z.

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