Annexins-a Family of Proteins with Distinctive Tastes for Cell Signaling and Membrane Dynamics

Overview

Journal Nat Commun

Specialty Biology

Date 2024 Feb 21

PMID 38383560

Authors

Volker Gerke

Felicity N E Gavins

Michael Geisow

Thomas Grewal

Jyoti K Jaiswal

Jesper Nylandsted

Ursula Rescher

Affiliations

Soon will be listed here.

Abstract

Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic phospholipids in cellular membranes at elevated Ca levels. Through this they act as Ca-regulated membrane binding modules that organize membrane lipids, facilitating cellular membrane transport but also displaying extracellular activities. Recent discoveries highlight annexins as sensors and regulators of cellular and organismal stress, controlling inflammatory reactions in mammals, environmental stress in plants, and cellular responses to plasma membrane rupture. Here, we describe the role of annexins as Ca-regulated membrane binding modules that sense and respond to cellular stress and share our view on future research directions in the field.

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