Puerarin Protects the Fatty Liver from Ischemia-reperfusion Injury by Regulating the PI3K/AKT Signaling Pathway

Overview

Journal Braz J Med Biol Res

Specialties Biology
General Medicine

Date 2024 Feb 21

PMID 38381885

Authors

Faji Yang

Hengjun Gao

Zheyu Niu

Qingqiang Ni

Huaqiang Zhu

Jianlu Wang

Jun Lu

Affiliations

Soon will be listed here.

Abstract

The incidence of non-alcoholic fatty liver (NAFLD) remains high, and many NAFLD patients suffer from severe ischemia-reperfusion injury (IRI). Currently, no practical approach can be used to treat IRI. Puerarin plays a vital role in treating multiple diseases, such as NAFLD, stroke, diabetes, and high blood pressure. However, its role in the IRI of the fatty liver is still unclear. We aimed to explore whether puerarin could protect the fatty liver from IRI. C57BL/6J mice were fed with a high-fat diet (HFD) followed by ischemia reperfusion injury. We showed that hepatic IRI was more severe in the fatty liver compared with the normal liver, and puerarin could significantly protect the fatty liver against IRI and alleviate oxidative stress. The PI3K-AKT signaling pathway was activated during IRI, while liver steatosis decreased the level of activation. Puerarin significantly protected the fatty liver from IRI by reactivating the PI3K-AKT signaling pathway. However, LY294002, a PI3K-AKT inhibitor, attenuated the protective effect of puerarin. In conclusion, puerarin could significantly protect the fatty liver against IRI by activating the PI3K-AKT signaling pathway.

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