Endogenous IL-27 During Toxoplasmosis Limits Early Monocyte Responses and Their Inflammatory Activation by Pathological T Cells

Overview

Journal mBio

Publisher American Society for Microbiology

Specialty Microbiology

Date 2024 Feb 20

PMID 38376210

Authors

Daniel L Aldridge

Devapregasan Moodley

Jeongho Park

Anthony T Phan

Matthew Rausch

Kerry F White

Yue Ren

Karin Golin

Enrico Radaelli

Ross Kedl

Pamela M Holland

Jonathan Hill

Christopher A Hunter

Affiliations

Soon will be listed here.

Abstract

Importance: The molecule IL-27 is critical in limiting the immune response to the parasite . In the absence of IL-27, a lethal, overactive immune response develops during infection. However, when exactly in the course of infection this molecule is needed was unclear. By selectively inhibiting IL-27 during this parasitic infection, we discovered that IL-27 was only needed during, but not prior to, infection. Additionally, IL-27 is only needed in the active areas in which the parasite is replicating. Finally, our work found that a previously unstudied cell type, monocytes, was regulated by IL-27, which contributes further to our understanding of the regulatory networks established by this molecule.

Citing Articles

IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion.

Aldridge D, Lanzar Z, Phan A, Christian D, Pardy R, Min B bioRxiv. 2025; .

PMID: 39868131 PMC: 11761129. DOI: 10.1101/2025.01.15.633135.

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