Identification of Mutants with Increased Daptomycin Resistance

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2024 Feb 20

PMID 38376203

Authors

Brianne R Zbylicki

Claire E Murphy

Jennifer A Petsche

Ute Muh

Horia A Dobrila

Theresa D Ho

Mikaela N Daum

Anthony G Pannullo

David S Weiss

Craig D Ellermeier

Affiliations

Soon will be listed here.

Abstract

Importance: is the leading cause of healthcare-associated diarrhea and is a threat to public health due to the risk of recurrent infections. Understanding biosynthesis of the atypical cell envelope of may provide insight into novel drug targets to selectively inhibit . Here, we identified mutations that increased daptomycin resistance and allowed us to better understand phospholipid synthesis, cell envelope biogenesis, and stress response in .

Citing Articles

Identification of two glycosyltransferases required for synthesis of membrane glycolipids in .

Zbylicki B, Cochran S, Weiss D, Ellermeier C mBio. 2025; 16(3):e0351224.

PMID: 39964170 PMC: 11898633. DOI: 10.1128/mbio.03512-24.

Identification of two glycosyltransferases required for synthesis of membrane glycolipids in .

Zbylicki B, Cochran S, Weiss D, Ellermeier C bioRxiv. 2025; .

PMID: 39868222 PMC: 11761805. DOI: 10.1101/2025.01.14.632984.

Identification of a family of peptidoglycan transpeptidases reveals that requires noncanonical cross-links for viability.

Bollinger K, Muh U, Ocius K, Apostolos A, Pires M, Helm R Proc Natl Acad Sci U S A. 2024; 121(34):e2408540121.

PMID: 39150786 PMC: 11348318. DOI: 10.1073/pnas.2408540121.

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