Lipid Metabolism As a Potential Target of Liver Cancer

Overview

Journal J Hepatocell Carcinoma

Date 2024 Feb 20

PMID 38375401

Authors

Kangze Wu

Feizhuan Lin

Affiliations

Soon will be listed here.

Abstract

Hepatocellular carcinoma (HCC) stands as a severe malignant tumor with a profound impact on overall health, often accompanied by an unfavorable prognosis. Despite some advancements in the diagnosis and treatment of this disease, improving the prognosis of HCC remains a formidable challenge. It is noteworthy that lipid metabolism plays a pivotal role in the onset, development, and progression of tumor cells. Existing research indicates the potential application of targeting lipid metabolism in the treatment of HCC. This review aims to thoroughly explore the alterations in lipid metabolism in HCC, offering a detailed account of the potential advantages associated with innovative therapeutic strategies targeting lipid metabolism. Targeting lipid metabolism holds promise for potentially enhancing the prognosis of HCC.

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References

Ma L, Wang L, Nelson A, Han C, He S, Henn M . 27-Hydroxycholesterol acts on myeloid immune cells to induce T cell dysfunction, promoting breast cancer progression. Cancer Lett. 2020; 493:266-283. PMC: 7572761. DOI: 10.1016/j.canlet.2020.08.020. View

Shi J, Fu H, Jia Z, He K, Fu L, Wang W . High Expression of CPT1A Predicts Adverse Outcomes: A Potential Therapeutic Target for Acute Myeloid Leukemia. EBioMedicine. 2016; 14:55-64. PMC: 5161445. DOI: 10.1016/j.ebiom.2016.11.025. View

Wang Y, Viscarra J, Kim S, Sul H . Transcriptional regulation of hepatic lipogenesis. Nat Rev Mol Cell Biol. 2015; 16(11):678-89. PMC: 4884795. DOI: 10.1038/nrm4074. View

Srivastava S, Widmann S, Ho C, Nguyen D, Nguyen A, Premaratne A . Novel Liver X Receptor Ligand GAC0001E5 Disrupts Glutamine Metabolism and Induces Oxidative Stress in Pancreatic Cancer Cells. Int J Mol Sci. 2020; 21(24). PMC: 7767092. DOI: 10.3390/ijms21249622. View

Ray K . Bempedoic Acid to Lower LDL Cholesterol - Safety and Efficacy. Reply. N Engl J Med. 2020; 383(7):e49. DOI: 10.1056/NEJMc1908495. View

Luo J, Yang H, Song B . Mechanisms and regulation of cholesterol homeostasis. Nat Rev Mol Cell Biol. 2019; 21(4):225-245. DOI: 10.1038/s41580-019-0190-7. View

Bene H, Lasky D, Ntambi J . Cloning and characterization of the human stearoyl-CoA desaturase gene promoter: transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol. Biochem Biophys Res Commun. 2001; 284(5):1194-8. DOI: 10.1006/bbrc.2001.5102. View

Watt M, Miotto P, De Nardo W, Montgomery M . The Liver as an Endocrine Organ-Linking NAFLD and Insulin Resistance. Endocr Rev. 2019; 40(5):1367-1393. DOI: 10.1210/er.2019-00034. View

Llovet J, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc J . Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008; 359(4):378-90. DOI: 10.1056/NEJMoa0708857. View

10.

Moffett J, Puthillathu N, Vengilote R, Jaworski D, Namboodiri A . Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics, and Oncogenesis - Part 2: Acetate and ACSS2 in Health and Disease. Front Physiol. 2020; 11:580171. PMC: 7693462. DOI: 10.3389/fphys.2020.580171. View

11.

Wu T, Luo G, Lian Q, Sui C, Tang J, Zhu Y . Discovery of a Carbamoyl Phosphate Synthetase 1-Deficient HCC Subtype With Therapeutic Potential Through Integrative Genomic and Experimental Analysis. Hepatology. 2021; 74(6):3249-3268. DOI: 10.1002/hep.32088. View

12.

Bechmann L, Hannivoort R, Gerken G, Hotamisligil G, Trauner M, Canbay A . The interaction of hepatic lipid and glucose metabolism in liver diseases. J Hepatol. 2011; 56(4):952-64. DOI: 10.1016/j.jhep.2011.08.025. View

13.

Garcia-Bermudez J, Baudrier L, Bayraktar E, Shen Y, La K, Guarecuco R . Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. Nature. 2019; 567(7746):118-122. PMC: 6405297. DOI: 10.1038/s41586-019-0945-5. View

14.

Carbone M, Melino G . Stearoyl CoA Desaturase Regulates Ferroptosis in Ovarian Cancer Offering New Therapeutic Perspectives. Cancer Res. 2019; 79(20):5149-5150. DOI: 10.1158/0008-5472.CAN-19-2453. View

15.

McGlynn K, London W . The global epidemiology of hepatocellular carcinoma: present and future. Clin Liver Dis. 2011; 15(2):223-43, vii-x. PMC: 4141529. DOI: 10.1016/j.cld.2011.03.006. View

16.

Rough J, Monroy M, Yerrum S, Daly J . Anti-proliferative effect of LXR agonist T0901317 in ovarian carcinoma cells. J Ovarian Res. 2010; 3:13. PMC: 2890636. DOI: 10.1186/1757-2215-3-13. View

17.

Mok E, Leung C, Zhou L, Lei M, Leung H, Tong M . Caspase-3-Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma. Cancer Res. 2022; 82(17):3102-3115. DOI: 10.1158/0008-5472.CAN-21-2934. View

18.

Nelson G, Ahlborn G, Allen J, Ren H, Corton J, Waalkes M . Transcriptional changes associated with reduced spontaneous liver tumor incidence in mice chronically exposed to high dose arsenic. Toxicology. 2009; 266(1-3):6-15. PMC: 7316389. DOI: 10.1016/j.tox.2009.10.004. View

19.

Aguirre-Portoles C, Feliu J, Reglero G, Ramirez de Molina A . ABCA1 overexpression worsens colorectal cancer prognosis by facilitating tumour growth and caveolin-1-dependent invasiveness, and these effects can be ameliorated using the BET inhibitor apabetalone. Mol Oncol. 2018; 12(10):1735-1752. PMC: 6166002. DOI: 10.1002/1878-0261.12367. View

20.

Chen Y, Yang X, Chen Y, Chen G, Winkler C, An P . Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma. BMC Cancer. 2021; 21(1):615. PMC: 8152151. DOI: 10.1186/s12885-021-08245-1. View