Exploring -methyladenosine (mA) Modification in Tree Species: Opportunities and Challenges

Overview

Journal Hortic Res

Publisher Oxford University Press

Date 2024 Feb 19

PMID 38371641

Authors

Muthusamy Ramakrishnan

K Shanmugha Rajan

Sileesh Mullasseri

Zishan Ahmad

Mingbing Zhou

Anket Sharma

Subbiah Ramasamy

Qiang Wei

Affiliations

Soon will be listed here.

Abstract

-methyladenosine (mA) in eukaryotes is the most common and widespread internal modification in mRNA. The modification regulates mRNA stability, translation efficiency, and splicing, thereby fine-tuning gene regulation. In plants, mA is dynamic and critical for various growth stages, embryonic development, morphogenesis, flowering, stress response, crop yield, and biomass. Although recent high-throughput sequencing approaches have enabled the rapid identification of mA modification sites, the site-specific mechanism of this modification remains unclear in trees. In this review, we discuss the functional significance of mA in trees under different stress conditions and discuss recent advancements in the quantification of mA. Quantitative and functional insights into the dynamic aspect of mA modification could assist researchers in engineering tree crops for better productivity and resistance to various stress conditions.

Citing Articles

Identification of mA RNA methylation genes in and expression profiling in response to different developmental and environmental stimuli.

Hasan M, Nishat Z, Hasan M, Hossain T, Ghosh A Biochem Biophys Rep. 2024; 38:101677.

PMID: 38511186 PMC: 10950732. DOI: 10.1016/j.bbrep.2024.101677.

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