First Use of Adeno-associated Viruses in the Human Inner Ear

Overview

Journal Mol Ther Methods Clin Dev

Publisher Cell Press

Date 2024 Feb 19

PMID 38371610

Authors

Lukas D Landegger

Affiliations

Soon will be listed here.

References

Dieter A, Keppeler D, Moser T . Towards the optical cochlear implant: optogenetic approaches for hearing restoration. EMBO Mol Med. 2020; 12(4):e11618. PMC: 7136966. DOI: 10.15252/emmm.201911618. View

Andres-Mateos E, Landegger L, Unzu C, Phillips J, Lin B, Dewyer N . Choice of vector and surgical approach enables efficient cochlear gene transfer in nonhuman primate. Nat Commun. 2022; 13(1):1359. PMC: 8924271. DOI: 10.1038/s41467-022-28969-3. View

Chow M, Ayiotis A, Schoo D, Gimmon Y, Lane K, Morris B . Posture, Gait, Quality of Life, and Hearing with a Vestibular Implant. N Engl J Med. 2021; 384(6):521-532. PMC: 8477665. DOI: 10.1056/NEJMoa2020457. View

Lembacher M, Arnoldner C, Landegger L . Patient Acceptance of Novel Therapeutic Options for Sensorineural Hearing Loss-A Pilot Study. Otol Neurotol. 2023; 44(4):e204-e210. DOI: 10.1097/MAO.0000000000003828. View

Akil O, Dyka F, Calvet C, Emptoz A, Lahlou G, Nouaille S . Dual AAV-mediated gene therapy restores hearing in a DFNB9 mouse model. Proc Natl Acad Sci U S A. 2019; 116(10):4496-4501. PMC: 6410774. DOI: 10.1073/pnas.1817537116. View

Zhang L, Wang H, Xun M, Tang H, Wang J, Lv J . Preclinical evaluation of the efficacy and safety of AAV1-hOTOF in mice and nonhuman primates. Mol Ther Methods Clin Dev. 2023; 31:101154. PMC: 10679773. DOI: 10.1016/j.omtm.2023.101154. View

Ivanchenko M, Hanlon K, Hathaway D, Klein A, Peters C, Li Y . AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear. Mol Ther Methods Clin Dev. 2021; 21:382-398. PMC: 8044388. DOI: 10.1016/j.omtm.2021.03.019. View

Gyorgy B, Meijer E, Ivanchenko M, Tenneson K, Emond F, Hanlon K . Gene Transfer with AAV9-PHP.B Rescues Hearing in a Mouse Model of Usher Syndrome 3A and Transduces Hair Cells in a Non-human Primate. Mol Ther Methods Clin Dev. 2018; 13:1-13. PMC: 6297893. DOI: 10.1016/j.omtm.2018.11.003. View

Al-Moyed H, Cepeda A, Jung S, Moser T, Kugler S, Reisinger E . A dual-AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock-out mice. EMBO Mol Med. 2018; 11(1). PMC: 6328916. DOI: 10.15252/emmm.201809396. View

10.

Fakhiri J, Landegger L, Grimm D . Breaking the sound barrier: Towards next-generation AAV vectors for gene therapy of hearing disorders. Hear Res. 2020; 413:108092. DOI: 10.1016/j.heares.2020.108092. View