From the Regulatory Mechanism of TFEB to Its Therapeutic Implications

Overview

Journal Cell Death Discov

Date 2024 Feb 16

PMID 38365838

Authors

Huixia Chen

Siqiao Gong

Hongyong Zhang

Yongming Chen

Yonghan Liu

Junfeng Hao

Huafeng Liu

Xiaoyu Li

Affiliations

Soon will be listed here.

Abstract

Transcription factor EB (TFEB), known as a major transcriptional regulator of the autophagy-lysosomal pathway, regulates target gene expression by binding to coordinated lysosomal expression and regulation (CLEAR) elements. TFEB are regulated by multiple links, such as transcriptional regulation, post-transcriptional regulation, translational-level regulation, post-translational modification (PTM), and nuclear competitive regulation. Targeted regulation of TFEB has been victoriously used as a treatment strategy in several disease models such as ischemic injury, lysosomal storage disorders (LSDs), cancer, metabolic disorders, neurodegenerative diseases, and inflammation. In this review, we aimed to elucidate the regulatory mechanism of TFEB and its applications in several disease models by targeting the regulation of TFEB as a treatment strategy.

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