Sex Differences and Racial/ethnic Disparities in the Presentation and Treatment of Medullary Thyroid Cancer

Overview

Journal Am J Surg

Specialty General Surgery

Date 2024 Feb 16

PMID 38365554

Authors

Saiesh Kalva

Sara P Ginzberg

Jesse E Passman

Jacqueline M Soegaard Ballester

Caitlin B Finn

Douglas L Fraker

Rachel R Kelz

Heather Wachtel

Affiliations

Soon will be listed here.

Abstract

Background: This study assessed for disparities in the presentation and management of medullary thyroid cancer (MTC).

Methods: Patients with MTC (2010-2020) were identified from the National Cancer Database. Differences in disease presentation and likelihood of guideline-concordant surgical management (total thyroidectomy and resection of ≥1 lymph node) were assessed by sex and race/ethnicity.

Results: Of 6154 patients, 68.2% underwent guideline-concordant surgery. Tumors >4 cm were more likely in men (vs. women: OR 2.47, p < 0.001) and Hispanic patients (vs. White patients: OR 1.52, p = 0.001). Non-White patients were more likely to have distant metastases (Black: OR 1.63, p = 0.002; Hispanic: OR 1.44, p = 0.038) and experienced longer time to surgery (Black: HR 0.66, p < 0.001; Hispanic: HR 0.71, p < 0.001). Black patients were less likely to undergo guideline-concordant surgery (OR 0.70, p = 0.022).

Conclusions: Male and non-White patients with MTC more frequently present with advanced disease, and Black patients are less likely to undergo guideline-concordant surgery.

Citing Articles

Critically evaluated key points on hereditary medullary thyroid carcinoma.

Zhang D, Liang N, Sun H, Frattini F, Sui C, Yang M Front Endocrinol (Lausanne). 2024; 15:1412942.

PMID: 38919477 PMC: 11197075. DOI: 10.3389/fendo.2024.1412942.

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