Intestinal Lysozyme1 Deficiency Alters Microbiota Composition and Impacts Host Metabolism Through the Emergence of NAD-secreting Bacteria

Overview

Journal mSystems

Publisher American Society for Microbiology

Specialty Microbiology

Date 2024 Feb 16

PMID 38364095

Authors

Chengye Zhang

Chen Xiang

Kaichen Zhou

Xingchen Liu

Guofeng Qiao

Yabo Zhao

Kemeng Dong

Ke Sun

Zhihua Liu

Affiliations

Soon will be listed here.

Abstract

Importance: The impact of intestinal lumen lysozyme on intestinal health is complex, arising from its multifaceted interactions with the gut microbiota. Lysozyme can both mitigate and worsen certain health conditions, varying with different scenarios. This underscores the necessity of identifying the specific bacterial responses elicited by lysozyme and understanding their molecular foundations. Our research reveals that a deficiency in intestinal lysozyme1 may offer protection against diet-induced obesity by altering bacterial populations. We discovered a strain of bacterium, , which secretes NAD and is predominantly found in lyz1-deficient mice. demonstrates positive effects in both and mouse models of ataxia telangiectasia. This study sheds light on the intricate role of lysozyme in influencing intestinal health.

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