Time-resolved Map of Serum Metabolome Profiling in D-galactose-induced Aging Rats with Exercise Intervention

Overview

Journal iScience

Publisher Cell Press

Date 2024 Feb 16

PMID 38362265

Authors

Xue Li

Changling Wei

Yu Jin

Jinmei Zhang

Pei Zhong

Deman Zhang

Xiaohan Huang

Affiliations

Soon will be listed here.

Abstract

Exercise, an intervention with wide-ranging effects on the whole body, has been shown to delay aging. Due to aging and exercise as modulator of metabolism, a picture of how exercise delayed D-galactose (D-gal)-induced aging in a time-resolved manner was presented in this paper. The mapping of molecular changes in response to exercise has become increasingly accessible with the development of omics techniques. To explore the dynamic changes during exercise, the serum of rats and D-gal-induced aging rats before, during, and after exercise was analyzed by untargeted metabolomics. The variation of metabolites was monitored to reveal the specific response to D-gal-induced senescence and exercise in multiple pathways, especially the basal amino acid metabolism, including glycine serine and threonine metabolism, cysteine and methionine metabolism, and tryptophan metabolism. The homeostasis was disturbed by D-gal and maintained by exercise. The paper was expected to provide a theoretical basis for the study of anti-aging exercise.

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