Association Between the Risk of Multiple Sclerosis and Dietary Proinflammatory/Anti-Inflammatory Food Intake and Dietary Diversity: A Case-Control Study

Overview

Journal Clin Nutr Res

Date 2024 Feb 16

PMID 38362132

Authors

Alireza Hatami

Maryam Ahmadi-Khorram

Fatemeh Keykhaei

Ali Jafarzadeh Esfehani

Mohsen Nematy

Affiliations

Soon will be listed here.

Abstract

A diet rich in proinflammatory components and inflammation are suggested to be significant risk factors for multiple sclerosis (MS). This study aimed to investigate the association between the risk of MS and the inflammatory potential of an individual's diet and dietary diversity through pro-inflammatory/anti-inflammatory food intake score (PAIFIS) and dietary diversity score (DDS). In a hospital-based case-control study, 397 participants, including 197 patients with MS and 200 healthy participants aged over 18 years, were evaluated. The history of smoking, dietary intake, and anthropometric characteristics, including body mass index, waist circumference, total body fat, and fat-free mass were assessed. A validated 160-item semiquantitative food frequency questionnaire was used to calculate the PAIFIS and DDS scores. The mean age of the participants was 32.45 ± 8.66 years, and most were females (274, 79.4%). The PAIFIS score was significantly higher among MS patients than healthy participants (p = 0.001). Between PAIFIS and DDS, only PAFIS was significantly related to MS risk (odds ratio, 1.002; 95% confidence interval, 1.001-1.004; p = 0.001). PAIFIS, as an index of dietary inflammation, can predict MS. Further studies are needed to document these findings.

Citing Articles

Dietary acid load as well as dietary phytochemical index, and association with multiple sclerosis: results from a case-control study.

Hatami A, Ahmadi-Khorram M, Keykhaei F, Hashemi M, Javid R, Hashempour M BMC Nutr. 2024; 10(1):93.

PMID: 38951946 PMC: 11218216. DOI: 10.1186/s40795-024-00897-z.

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