Experimental Endocarditis and Fosfomycin

Overview

Journal Drugs Exp Clin Res

Date 1985 Jan 1

PMID 3836112

Citations 3

Authors

A Rodriguez

M V Vicente

T Olay

Affiliations

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Abstract

The effectiveness of fosfomycin in combination with other antibiotics was studied in vitro and in the treatment of left-sided endocarditis in rabbits caused by S. sanguis, S. faecalis, S. aureus or P. aeruginosa. In vitro combinations of fosfomycin plus penicillin, fosfomycin plus cloxacillin, and fosfomycin plus amikacin were synergistic against the strains tested. In vivo synergism was also demonstrated since fosfomycin combinations produced a greater reduction in the number of CFU/g of vegetations than the administration of one antibiotic alone.

Citing Articles

Fosfomycin enhances the active transport of tobramycin in Pseudomonas aeruginosa.

Macleod D, Velayudhan J, Kenney T, Therrien J, Sutherland J, Barker L Antimicrob Agents Chemother. 2012; 56(3):1529-38.

PMID: 22232284 PMC: 3294879. DOI: 10.1128/AAC.05958-11.

Fosfomycin: an old, new friend?.

Popovic M, Steinort D, Pillai S, Joukhadar C Eur J Clin Microbiol Infect Dis. 2009; 29(2):127-42.

PMID: 19915879 DOI: 10.1007/s10096-009-0833-2.

In vitro synergism between daptomycin and fosfomycin against Enterococcus faecalis isolates with high-level gentamicin resistance.

Rice L, Eliopoulos G, Moellering Jr R Antimicrob Agents Chemother. 1989; 33(4):470-3.

PMID: 2543282 PMC: 172462. DOI: 10.1128/AAC.33.4.470.