Bob1 Maintains T Follicular Helper Cells for Long-term Humoral Immunity

Overview

Journal Commun Biol

Specialty Biology

Date 2024 Feb 15

PMID 38360857

Authors

Masahiro Yanagi

Ippei Ikegami

Ryuta Kamekura

Tatsuya Sato

Taiki Sato

Shiori Kamiya

Kosuke Murayama

Sumito Jitsukawa

Fumie Ito

Akira Yorozu

Miho Kihara

Takaya Abe

Hiromi Takaki

Koji Kawata

Katsunori Shigehara

Satsuki Miyajima

Hirotaka Nishikiori

Akinori Sato

Noritsugu Tohse

Ken-ichi Takano

Hirofumi Chiba

Shingo Ichimiya

Affiliations

Soon will be listed here.

Abstract

Humoral immunity is vital for host protection, yet aberrant antibody responses can trigger harmful inflammation and immune-related disorders. T follicular helper (Tfh) cells, central to humoral immunity, have garnered significant attention for unraveling immune mechanisms. This study shows the role of B-cell Oct-binding protein 1 (Bob1), a transcriptional coactivator, in Tfh cell regulation. Our investigation, utilizing conditional Bob1-deficient mice, suggests that Bob1 plays a critical role in modulating inducible T-cell costimulator expression and cellular respiration in Tfh cells. This regulation maintains the long-term functionality of Tfh cells, enabling their reactivation from central memory T cells to produce antibodies during recall responses. In a bronchial asthma model induced by house dust mite (HDM) inhalation, Bob1 is observed to enhance HDM-specific antibodies, including IgE, highlighting its pivotal function in Tfh cell regulation. Further exploration of Bob1-dependent mechanisms in Tfh cells holds promise for governing protective immunity and addressing immune-related disorders.

Citing Articles

Interleukin 9 mediates T follicular helper cell activation to promote antibody responses.

Sato T, Ikegami I, Yanagi M, Ohyu T, Sugaya T, Shirato S Front Immunol. 2024; 15:1441407.

PMID: 39403384 PMC: 11471543. DOI: 10.3389/fimmu.2024.1441407.

Help me help you: emerging concepts in T follicular helper cell differentiation, identity, and function.

Wellford S, Schwartzberg P Curr Opin Immunol. 2024; 87:102421.

PMID: 38733669 PMC: 11482284. DOI: 10.1016/j.coi.2024.102421.

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