RNA Polymerase Collisions and Their Role in Transcription

Overview

Journal Transcription

Specialty Molecular Biology

Date 2024 Feb 15

PMID 38357902

Authors

Ling Wang

Affiliations

Soon will be listed here.

Abstract

RNA polymerases are the central enzymes of gene expression and function frequently in either a head-on or co-directional manner on the busy DNA track. Whether and how these collisions between RNA polymerases contribute to transcriptional regulation is mysterious. Increasing evidence from biochemical and single-molecule studies suggests that RNA polymerase collisions function as an important regulator to fine-tune transcription, rather than creating deleterious "traffic jams". This review summarizes the recent progress on elucidating the consequences of RNA polymerase collisions during transcription and highlights the significance of cooperation and coordination between RNA polymerases.

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