» Articles » PMID: 38357097

Plasma Amino Acids in Major Depressive Disorder: Between Pathology to Pharmacology

Overview
Journal EXCLI J
Specialty Biology
Date 2024 Feb 15
PMID 38357097
Authors
Affiliations
Soon will be listed here.
Abstract

Addressing the formidable challenge posed by the development of effective and personalized interventions for major depressive disorder (MDD) necessitates a comprehensive comprehension of the intricate role that plasma amino acids play and their implications in MDD pathology and pharmacology. Amino acids, owing to their indispensable functions in neurotransmission, metabolism, and immune regulation, emerge as pivotal entities in this intricate disorder. Our primary objective entails unraveling the underlying mechanisms and unveiling tailored treatments through a meticulous investigation into the interplay between plasma amino acids, MDD, and pharmacological strategies. By conducting a thorough and exhaustive review of the existing literature, we have identified pertinent studies on plasma amino acids in MDD, thereby uncovering noteworthy disturbances in the profiles of amino acids among individuals afflicted by MDD when compared to their healthy counterparts. Specifically, disruptions in the metabolism of tryptophan, phenylalanine, and tyrosine, which serve as precursors to essential neurotransmitters, have emerged as prospective biomarkers and critical contributors to the pathophysiology of depression. Amnio acids play an essential role in MDD and could represent an attractive pharmacological target, more studies are further required to fully reveal their underlying mechanisms.

Citing Articles

Serum Metabolites as Potential Markers and Predictors of Depression-like Behavior and Effective Fluoxetine Treatment in Chronically Socially Isolated Rats.

Filipovic D, Inderhees J, Korda A, Tadic P, Schwaninger M, Inta D Metabolites. 2024; 14(8).

PMID: 39195501 PMC: 11355999. DOI: 10.3390/metabo14080405.


Deciphering Depression: Epigenetic Mechanisms and Treatment Strategies.

Aljabali A, Alkaraki A, Gammoh O, Tambuwala M, Mishra V, Mishra Y Biology (Basel). 2024; 13(8).

PMID: 39194576 PMC: 11351889. DOI: 10.3390/biology13080638.

References
1.
Ansone L, Briviba M, Silamikelis I, Terentjeva A, Perkons I, Birzniece L . Amino Acid Metabolism is Significantly Altered at the Time of Admission in Hospital for Severe COVID-19 Patients: Findings from Longitudinal Targeted Metabolomics Analysis. Microbiol Spectr. 2021; 9(3):e0033821. PMC: 8653833. DOI: 10.1128/spectrum.00338-21. View

2.
Richard D, Dawes M, Mathias C, Acheson A, Hill-Kapturczak N, Dougherty D . L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications. Int J Tryptophan Res. 2011; 2:45-60. PMC: 2908021. DOI: 10.4137/ijtr.s2129. View

3.
Kasakin M, Rogachev A, Predtechenskaya E, Zaigraev V, Koval V, Pokrovsky A . Changes in Amino Acid and Acylcarnitine Plasma Profiles for Distinguishing Patients with Multiple Sclerosis from Healthy Controls. Mult Scler Int. 2020; 2020:9010937. PMC: 7378614. DOI: 10.1155/2020/9010937. View

4.
Carpenter L, Anderson G, Pelton G, Gudin J, Kirwin P, Price L . Tryptophan depletion during continuous CSF sampling in healthy human subjects. Neuropsychopharmacology. 1998; 19(1):26-35. DOI: 10.1016/S0893-133X(97)00198-X. View

5.
Ho C, Tay G, Wee H, Ching J . The Utility of Amino Acid Metabolites in the Diagnosis of Major Depressive Disorder and Correlations with Depression Severity. Int J Mol Sci. 2023; 24(3). PMC: 9916471. DOI: 10.3390/ijms24032231. View