Hypoxia-triggered Degradable Porphyrinic Covalent Organic Framework for Synergetic Photodynamic and Photothermal Therapy of Cancer

Overview

Journal Mater Today Bio

Specialty Biomedical Engineering

Date 2024 Feb 15

PMID 38356961

Authors

Yulong Liu

Kang Yang

Jun Wang

Yanzhang Tian

Bin Song

Ruiping Zhang

Affiliations

Soon will be listed here.

Abstract

Nanomedicines receive great attention in cancer treatment. Nevertheless, nonbiodegradable and long-term retention still limit their clinical translation. Herein, we successfully synthesize a hypoxia-triggered degradable porphyrinic covalent organic framework (HPCOF) for antitumor therapy . HPCOF possesses wide absorption in near infrared region (NIR) which endows HPCOF excellent photothermal conversion efficiency and photoacoustic (PA) imaging ability. Moreover, HPCOF exhibits excellent photodynamic and photothermal effect under special-wavelength laser irradiation. For the first time, the and tests demonstrate that HPCOF shows effective therapeutic effect for the combination of PDT and PTT under the monitoring of PA imaging. Importantly, in tumor region, HPCOF could be triggered by hypoxia microenvironment and collapsed gradually, then cleared from the body after treatment. This work fabricates a novel COF for cancer treatment and testifies great potential of HPCOF in clinical application with reducing long-term toxicity.

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PMID: 38800565 PMC: 11126933. DOI: 10.1016/j.mtbio.2024.101091.

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