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Traditional Chinese Medicine-based Treatment in Cardiovascular Disease: Potential Mechanisms of Action

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Date 2024 Feb 13
PMID 38347793
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Abstract

Cardiovascular Disease (CVD) is the leading cause of morbidity and death worldwide and has become a global public health problem. Traditional Chinese medicine (TCM) has been used in China to treat CVD and achieved promising results. Therefore, TCM has aroused significant interest among pharmacologists and medical practitioners. Previous research showed that TCM can regulate the occurrence and development of atherosclerosis (AS), ischemic heart disease, heart failure, myocardial injury, and myocardial fibrosis by inhibiting vascular endothelial injury, inflammation, oxidant stress, ischemia-reperfusion injury, and myocardial remodeling. It is well-known that TCM has the characteristics of multi-component, multi-pathway, and multitarget. Here, we systematically review the bioactive components, pharmacological effects, and clinical application of TCM in preventing and treating CVD.

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References
1.
Wang T, Wu Z, Sun L, Li W, Liu G, Tang Y . A Computational Systems Pharmacology Approach to Investigate Molecular Mechanisms of Herbal Formula Tian-Ma-Gou-Teng-Yin for Treatment of Alzheimer's Disease. Front Pharmacol. 2018; 9:668. PMC: 6028720. DOI: 10.3389/fphar.2018.00668. View

2.
Man B, Hu C, Yang G, Xiang J, Yang S, Ma C . Berberine attenuates diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARα in ApoE mice. Biochem Biophys Res Commun. 2022; 624:59-67. DOI: 10.1016/j.bbrc.2022.07.072. View

3.
Mannino F, Pallio G, Altavilla D, Squadrito F, Vermiglio G, Bitto A . Atherosclerosis Plaque Reduction by Lycopene Is Mediated by Increased Energy Expenditure through AMPK and PPARα in ApoE KO Mice Fed with a High Fat Diet. Biomolecules. 2022; 12(7). PMC: 9313394. DOI: 10.3390/biom12070973. View

4.
Ni Y, Zhang J, Zhu W, Duan Y, Bai H, Luan C . Echinacoside inhibited cardiomyocyte pyroptosis and improved heart function of HF rats induced by isoproterenol via suppressing NADPH/ROS/ER stress. J Cell Mol Med. 2022; 26(21):5414-5425. PMC: 9639035. DOI: 10.1111/jcmm.17564. View

5.
Yang Q, Xu Y, Shen L, Pan Y, Huang J, Ma Q . Guanxinning Tablet Attenuates Coronary Atherosclerosis via Regulating the Gut Microbiota and Their Metabolites in Tibetan Minipigs Induced by a High-Fat Diet. J Immunol Res. 2022; 2022:7128230. PMC: 9352486. DOI: 10.1155/2022/7128230. View