Enhanced Efficiency of Pd(0)-Based Single Chain Polymeric Nanoparticles for Prodrug Activation by Modulating the Polymer's Microstructure

Overview

Journal Nano Lett

Publisher American Chemical Society

Specialty Biotechnology

Date 2024 Feb 12

PMID 38346395

Authors

Linlin Deng

Anjana Sathyan

Catherine Adam

Asier Unciti-Broceta

Victor Sebastian

Anja R A Palmans

Affiliations

Soon will be listed here.

Abstract

Bioorthogonal catalysis employing transition metal catalysts is a promising strategy for the synthesis of imaging and therapeutic agents in biological environments. The transition metal Pd has been widely used as a bioorthogonal catalyst, but bare Pd poses challenges in water solubility and catalyst stability in cellular environments. In this work, Pd(0) loaded amphiphilic polymeric nanoparticles are applied to shield Pd in the presence of living cells for the generation of a fluorescent dye and anticancer drugs. Pd(0) loaded polymeric nanoparticles prepared by the reduction of the corresponding Pd(II)-polymeric nanoparticles are highly active in the deprotection of pro-rhodamine dye and anticancer prodrugs, giving significant fluorescence enhancement and toxigenic effects, respectively, in HepG2 cells. In addition, we show that the microstructure of the polymeric nanoparticles for scaffolding Pd plays a critical role in tuning the catalytic efficiency, with the use of the ligand triphenylphosphine as a key factor for improving the catalyst stability in biological environments.

Citing Articles

Effect of Particle Heterogeneity in Catalytic Copper-Containing Single-Chain Polymeric Nanoparticles Revealed by Single-Particle Kinetics.

Sathyan A, Archontakis E, Spiering A, Albertazzi L, Palmans A Molecules. 2024; 29(8).

PMID: 38675670 PMC: 11054931. DOI: 10.3390/molecules29081850.

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