Plasma Fibrinogen: a Driver of Left Ventricular Remodeling in Patients Undergoing Peritoneal Dialysis and Its Related Risk Factors

Overview

Journal Ren Fail

Publisher Informa Healthcare

Date 2024 Feb 12

PMID 38346031

Authors

Yun Chen

Shuqi Dai

Xiaolin Ge

Da Shang

Qionghong Xie

ChuanMing Hao

Tongying Zhu

Affiliations

Soon will be listed here.

Abstract

Background And Aim: Plasma fibrinogen has been proven to be significantly associated with cardiovascular mortality in patients undergoing peritoneal dialysis (PD). The study aimed to investigate the role of fibrinogen in left ventricular (LV) remodeling and functions in patients on PD, and explore risk factors related to high fibrinogen level.

Methods: From February 2008 to July 2018, adult patients on regular PD for at least 1 month were recruited and followed up for two years. Correlation analysis was performed to explore the fibrinogen level and echocardiography measurements. Pathogenic factors correlated to the left ventricular hypertrophy (LVH) progression were explored by logistic regression models and the role of fibrinogen in it was verified by receiver operating characteristic (ROC) curves. Linear regression models were conducted to identify factors associated with fibrinogen level.

Results: A total of 278 patients undergoing PD (168 males, 60.4%) were recruited. Patients were trisected according to fibrinogen levels at baseline. Mean wall thickness (MWT), relative wall thickness (RWT), and left ventricular mass index (LVMI) were positively associated with fibrinogen level while / ratio was negatively associated with it. Multivariate logistic regression and ROC curve showed that fibrinogen was an independent risk factor for LVH progression. Multivariate linear regression analysis identified age, total cholesterol (CHO), fasting blood glucose (FBG), and high-sensitivity C-reactive protein (hsCRP) were significantly related to plasma fibrinogen level.

Conclusions: An elevated fibrinogen level was independently associated with LVH progression in patients undergoing PD. Older age, higher level of FBG, CHO, and hsCRP were risk factors for elevated plasma fibrinogen level.

Citing Articles

Hallmarks for Thrombotic and Hemorrhagic Risks in Chronic Kidney Disease Patients.

Saeed Z, Sirolli V, Bonomini M, Gallina S, Renda G Int J Mol Sci. 2024; 25(16).

PMID: 39201390 PMC: 11354877. DOI: 10.3390/ijms25168705.

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