ITGB2 Fosters the Cancerous Characteristics of Ovarian Cancer Cells Through Its Role in Mitochondrial Glycolysis Transformation

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2024 Feb 12

PMID 38345576

Authors

Guo-Wei Li

Yan-Ping Jin

Jian-Ping Qiu

Xiu-Fang Lu

Affiliations

Soon will be listed here.

Abstract

Related studies have shown that ITGB2 mediates mitochondrial glycolytic transformation in cancer-associated fibroblasts and participates in tumor occurrence, metastasis and invasion of cancer cells. Based on these studies, we tried to construct a mitochondrial glycolysis regulatory network and explored its effect on mitochondrial homeostasis and ovarian cancer cells' cancerous characteristics. Our research revealed a distinct increase in the expression of ITGB2 and associated signaling pathway elements (PI3K-AKT-mTOR) in cases of ovarian cancer. ITGB2 might control mTOR expression via the PI3K-AKT pathway, thus promote mitochondrial glycolysis transformation and cell energy supply in ovarian cancer. This pathway could also inhibit mitophagy, maintain mitochondrial stability, and enhance the cancerous characteristics in case of ovarian cancer cells by mediating mitochondrial glycolytic transformation. Thus, we concluded that ITGB2-associated signaling route (PI3K-AKT-mTOR) may contribute to the progression of cancerous traits in ovarian cancer via mediating mitochondrial glycolytic transformation.

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