The Association Between Closed-eye Unipedal Standing and the Risk of Cognitive Impairment in the Elderly: a 7-year Community-based Cohort Study in Wuhan, China

Overview

Journal Front Aging Neurosci

Specialty Geriatrics

Date 2024 Feb 12

PMID 38343877

Authors

Shiwei Wang

Peng Guo

Chengjing Huang

Yuqian Zhang

Bing Xiang

Jing Zeng

Feng Zhou

Xinyan Xie

Yan Guo

Mei Yang

Affiliations

Soon will be listed here.

Abstract

Objectives: The prevention of cognitive impairment in the elderly is one of the public health priority areas. However, the relationship between closed-eye unipedal standing and cognitive impairment remains unclear.

Methods: This study was conducted on a group of elderly individuals from a community, using a prospective cohort study design. Participants were monitored for 7 years and were diagnosed with new-onset cognitive impairment. Logistic regression models and restricted cubic spline (RCS) were used to investigate the relationship between closed-eye unipedal standing and cognitive impairment. Stratified analysis by baseline characteristics were also performed.

Results: At baseline, 1,652 people aged 65 years or older were enrolled. Ultimately, 880 participants completed the follow-up and 155 (17.61%) of them satisfied the diagnostic criteria for cognitive impairment at follow-up. Compared to the closed-eye unipedal standing low group as the reference, the middle (OR = 0.601, 95% CI: 0.396-0.911) and high (OR = 0.508, 95% CI: 0.329-0.785) groups had significantly lower cognitive impairment risks. RCS analysis indicated a linear relationship ( = 0.177), with a reduced risk of developing cognitive impairment when the duration of closed-eye unipedal standing was exceeded ~2.920 s. Stratified analysis showed that for female, aged 70 years or younger, with 3 or more years of education, without lack of exercise and without falls within 1 year subgroup, the elderly in the high group of closed-eye unipedal standing had significantly reduced cognitive impairment risks.

Conclusion: Among the elderly population, closed-eye unipedal standing duration was linearly and negatively associated with the cognitive impairment risk. The closed-eye unipedal standing duration might be a predictive index for cognitive impairment in the elderly.

References

Jia X, Wang Z, Huang F, Su C, Du W, Jiang H . A comparison of the Mini-Mental State Examination (MMSE) with the Montreal Cognitive Assessment (MoCA) for mild cognitive impairment screening in Chinese middle-aged and older population: a cross-sectional study. BMC Psychiatry. 2021; 21(1):485. PMC: 8489046. DOI: 10.1186/s12888-021-03495-6. View

Hu M, Shu X, Yu G, Wu X, Valimaki M, Feng H . A Risk Prediction Model Based on Machine Learning for Cognitive Impairment Among Chinese Community-Dwelling Elderly People With Normal Cognition: Development and Validation Study. J Med Internet Res. 2021; 23(2):e20298. PMC: 7946590. DOI: 10.2196/20298. View

Yang H, Wu Y, Lin M, Liao S, Fan C, Wu C . Association between neighborhood availability of physical activity facilities and cognitive performance in older adults. Prev Med. 2023; 175:107669. DOI: 10.1016/j.ypmed.2023.107669. View

Prince M, Ali G, Guerchet M, Prina A, Albanese E, Wu Y . Recent global trends in the prevalence and incidence of dementia, and survival with dementia. Alzheimers Res Ther. 2016; 8(1):23. PMC: 4967299. DOI: 10.1186/s13195-016-0188-8. View

Jia L, Du Y, Chu L, Zhang Z, Li F, Lyu D . Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study. Lancet Public Health. 2020; 5(12):e661-e671. DOI: 10.1016/S2468-2667(20)30185-7. View

Morenilla L, Marquez G, Sanchez J, Bello O, Lopez-Alonso V, Fernandez-Lago H . Postural Stability and Cognitive Performance of Subjects With Parkinson's Disease During a Dual-Task in an Upright Stance. Front Psychol. 2020; 11:1256. PMC: 7438725. DOI: 10.3389/fpsyg.2020.01256. View

Sabia S, Dugravot A, Dartigues J, Abell J, Elbaz A, Kivimaki M . Physical activity, cognitive decline, and risk of dementia: 28 year follow-up of Whitehall II cohort study. BMJ. 2017; 357:j2709. PMC: 5480222. DOI: 10.1136/bmj.j2709. View

Pangman V, Sloan J, Guse L . An examination of psychometric properties of the mini-mental state examination and the standardized mini-mental state examination: implications for clinical practice. Appl Nurs Res. 2000; 13(4):209-13. DOI: 10.1053/apnr.2000.9231. View

Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S . Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020; 396(10248):413-446. PMC: 7392084. DOI: 10.1016/S0140-6736(20)30367-6. View

10.

Bustillo-Casero P, Villarrasa-Sapina I, Garcia-Masso X . Effects of dual task difficulty in motor and cognitive performance: Differences between adults and adolescents. Hum Mov Sci. 2017; 55:8-17. DOI: 10.1016/j.humov.2017.07.004. View

11.

Ahn J, Kim M . Effects of aerobic exercise on global cognitive function and sleep in older adults with mild cognitive impairment: A systematic review and meta-analysis. Geriatr Nurs. 2023; 51:9-16. DOI: 10.1016/j.gerinurse.2023.02.008. View

12.

Afschrift M, De Groote F, Jonkers I . Similar sensorimotor transformations control balance during standing and walking. PLoS Comput Biol. 2021; 17(6):e1008369. PMC: 8266079. DOI: 10.1371/journal.pcbi.1008369. View

13.

Serra-Ano P, Lopez-Bueno L, Garcia-Masso X, Pellicer-Chenoll M, Gonzalez L . POSTURAL CONTROL MECHANISMS IN HEALTHY ADULTS IN SITTING AND STANDING POSITIONS. Percept Mot Skills. 2015; 121(1):119-34. DOI: 10.2466/26.25.PMS.121c10x4. View

14.

Omura J, Brown D, McGuire L, Taylor C, Fulton J, Carlson S . Cross-sectional association between physical activity level and subjective cognitive decline among US adults aged ≥45 years, 2015. Prev Med. 2020; 141:106279. PMC: 10941305. DOI: 10.1016/j.ypmed.2020.106279. View

15.

Yoshimoto Y, Oyama Y, Tanaka M, Sakamoto A . One-Leg Standing Time of the Affected Side Moderately Predicts for Postdischarge Falls in Community Stroke Patients. J Stroke Cerebrovasc Dis. 2016; 25(8):1907-13. DOI: 10.1016/j.jstrokecerebrovasdis.2016.03.032. View

16.

Henry M, Baudry S . Age-related changes in leg proprioception: implications for postural control. J Neurophysiol. 2019; 122(2):525-538. PMC: 6734411. DOI: 10.1152/jn.00067.2019. View

17.

Pu L, Pan D, Wang H, He X, Zhang X, Yu Z . A predictive model for the risk of cognitive impairment in community middle-aged and older adults. Asian J Psychiatr. 2022; 79:103380. DOI: 10.1016/j.ajp.2022.103380. View

18.

Martinez-Amat A, Hita-Contreras F, Lomas-Vega R, Caballero-Martinez I, Alvarez P, Martinez-Lopez E . Effects of 12-week proprioception training program on postural stability, gait, and balance in older adults: a controlled clinical trial. J Strength Cond Res. 2012; 27(8):2180-8. DOI: 10.1519/JSC.0b013e31827da35f. View

19.

Lourenco J, Serrano A, Santos-Silva A, Gomes M, Afonso C, Freitas P . Cardiovascular Risk Factors Are Correlated with Low Cognitive Function among Older Adults Across Europe Based on The SHARE Database. Aging Dis. 2018; 9(1):90-101. PMC: 5772862. DOI: 10.14336/AD.2017.0128. View

20.

Arevalo-Rodriguez I, Smailagic N, Roque I Figuls M, Ciapponi A, Sanchez-Perez E, Giannakou A . Mini-Mental State Examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev. 2015; (3):CD010783. PMC: 6464748. DOI: 10.1002/14651858.CD010783.pub2. View