Significance of OCT3/4 and SOX2 Antigens Expression by Leukemic Blast Cells in Adult Acute Leukemia

Overview

Journal J Egypt Natl Canc Inst

Specialty Oncology

Date 2024 Feb 11

PMID 38342816

Authors

Salah Aref

Omnyia Khaled

Nadia El Menshawy

Emad Azmy

Mohamed Aref

Osama Salama

Nada Khaled

Affiliations

Soon will be listed here.

Abstract

Objective: This study aimed to address the prognostic impact of SOX2 and OCT3/4 expression on adult acute leukemia patients' outcomes.

Methods: SOX2 and OCT3/4 expression by blast cells were evaluated by flow cytometry in 80 acute leukemia patients and 8 healthy controls.

Results: Baseline SOX2 and OCT3/4 expression were significantly higher in both ALL (P = < 0.001, P = 0.005 respectively) and AML patients (P < 0.001, P = 0.003 respectively) as compared to control, and decline at complete remission (CR) and elevated again at relapse. High SOX2 and OCT3/4 levels were significantly correlated with the presence of adverse risk stratification parameters.

Conclusion: Our findings indicated that both SOX2 and OCT3/4 could serve as biomarkers that could improve risk stratification of acute leukemia patients. Also, both SOX2 and OCT3/4 might be a therapeutic target, especially in resistant acute leukemia.

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