Quantity and Quality of Minichromosome Maintenance Protein Complexes Couple Replication Licensing to Genome Integrity

Overview

Journal Commun Biol

Specialty Biology

Date 2024 Feb 9

PMID 38336851

Authors

Anoop Kumar Yadav

Hana Polasek-Sedlackova

Affiliations

Soon will be listed here.

Abstract

Accurate and complete replication of genetic information is a fundamental process of every cell division. The replication licensing is the first essential step that lays the foundation for error-free genome duplication. During licensing, minichromosome maintenance protein complexes, the molecular motors of DNA replication, are loaded to genomic sites called replication origins. The correct quantity and functioning of licensed origins are necessary to prevent genome instability associated with severe diseases, including cancer. Here, we delve into recent discoveries that shed light on the novel functions of licensed origins, the pathways necessary for their proper maintenance, and their implications for cancer therapies.

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