Lipid Regulation of Protocatechualdehyde and Hydroxysafflor Yellow A Via AMPK/SREBP2/PCSK9/LDLR Signaling Pathway in Hyperlipidemic Zebrafish

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Feb 9

PMID 38333845

Authors

Bingying Lin

Haofang Wan

Jiehong Yang

Li Yu

Huifen Zhou

Haitong Wan

Affiliations

Soon will be listed here.

Abstract

The consumption of a high-cholesterol diet is known to cause hyperlipidemia, which is one of the main risk factors for cardiovascular disease. Protocatechualdehyde (PCA) and hydroxysafflor yellow A (HSYA) are the active components of Salvia miltiorrhiza and safflower, respectively. However, their exact mechanism is still unclear. The aim of this study is to investigate its effects on lipid deposition and liver damage in hyperlipidemic zebrafish and its mechanism of anti-hyperlipidemia. The results showed that the use of PCA and HSYA alone and in combination can improve lipid deposition, slow behavior, abnormal blood flow and liver tissue damage, and the combined use is more effective. Further RT-qPCR results showed that PCA + HSYA can regulate the mRNA levels of , , , , , , , and . The PCA + HSYA significantly improves lipid deposition and abnormal liver function in hyperlipidemic zebrafish larvae, which may be related to the AMPK/SREBP2/PCSK9/LDLR signaling pathway.

Citing Articles

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