Age-related Hearing Loss: An Updated and Comprehensive Review of the Interventions

Overview

Journal Iran J Basic Med Sci

Publisher Mashhad University of Medical Sciences

Specialty General Medicine

Date 2024 Feb 9

PMID 38333758

Authors

Elham Tavanai

Vida Rahimi

Mohammad Ehsan Khalili

Somayeh Falahzadeh

Masoud Motasaddi Zarandy

Ghassem Mohammadkhani

Affiliations

Soon will be listed here.

Abstract

Aging causes progressive degenerative changes in many organs, particularly the auditory system. Several attempts have been conducted to investigate preventive and therapeutic strategy/strategies for age-related auditory dysfunction, such as maintaining a healthy lifestyle through good nutrition, lower anxiety levels, and noise exposure, different pharmacological approaches, gene and cell therapy, and other strategies. However, it is not clear which approach is the best to slow down these dysfunctions because several different underlying mechanistic pathways are associated with presbycusis which eventually leads to different types of this disease. A combination of several methods is probably required, whereas the effectiveness for some people needs to be monitored. The effectiveness of treatments will not be the same for all; therefore, we may need to have a unique and personalized approach to the prevention and treatment of ARHL for each person. In addition, each method needs to specify what type of presbycusis can prevent or treat and provide complete information about the extent, duration of treatment, persistency of treatment, side effects, and whether the approach is for treatment or prevention or even both. This paper reviews the updated literature, which targets current interventions for age-related hearing loss.

References

Derin A, Agirdir B, Derin N, Dinc O, Guney K, Ozcaglar H . The effects of L-carnitine on presbyacusis in the rat model. Clin Otolaryngol Allied Sci. 2004; 29(3):238-41. DOI: 10.1111/j.1365-2273.2004.00790.x. View

Kim T, Chung J . Associations of Dietary Riboflavin, Niacin, and Retinol with Age-related Hearing Loss: An Analysis of Korean National Health and Nutrition Examination Survey Data. Nutrients. 2019; 11(4). PMC: 6520829. DOI: 10.3390/nu11040896. View

Yu Y, Wu W, Xiao G, Ling H, Pan C . Protection of the cochlear hair cells in adult C57BL/6J mice by T-type calcium channel blockers. Exp Ther Med. 2016; 11(3):1039-1044. PMC: 4774483. DOI: 10.3892/etm.2016.2970. View

Sardone R, Lampignano L, Guerra V, Zupo R, Donghia R, Castellana F . Relationship between Inflammatory Food Consumption and Age-Related Hearing Loss in a Prospective Observational Cohort: Results from the Salus in Apulia Study. Nutrients. 2020; 12(2). PMC: 7071162. DOI: 10.3390/nu12020426. View

Bouzid A, Smeti I, Chakroun A, Loukil S, Gibriel A, Grati M . Methylation Status and Presbycusis Risk in Elderly Women. Front Aging Neurosci. 2018; 10:241. PMC: 6090039. DOI: 10.3389/fnagi.2018.00241. View

Miwa T . Protective Effects of N-Methylnicotinamide Against High-Fat Diet- and Age-Induced Hearing Loss Moderate Overexpression of Sirtuin 1 Protein. Front Cell Neurosci. 2021; 15:634868. PMC: 8055820. DOI: 10.3389/fncel.2021.634868. View

Price K, Zhu X, Guimaraes P, Vasilyeva O, Frisina R . Hormone replacement therapy diminishes hearing in peri-menopausal mice. Hear Res. 2009; 252(1-2):29-36. PMC: 2698030. DOI: 10.1016/j.heares.2009.02.010. View

Martinez-Vega R, Partearroyo T, Vallecillo N, Varela-Moreiras G, Pajares M, Varela-Nieto I . Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss in C57BL/6J mice. J Nutr Biochem. 2015; 26(12):1424-33. DOI: 10.1016/j.jnutbio.2015.07.011. View

Muderris T, Saglam A, Unsal D, Mulazimoglu S, Sevil E, Kayhan H . Efficiency of resveratrol in the prevention and treatment of age-related hearing loss. Exp Ther Med. 2021; 23(1):40. PMC: 8613532. DOI: 10.3892/etm.2021.10962. View

10.

Gopinath B, McMahon C, Lewis J, Bondonno N, Bondonno C, Burlutsky G . Associations between Intake of Dietary Flavonoids and 10-Year Incidence of Age-Related Hearing Loss. Nutrients. 2020; 12(11). PMC: 7693883. DOI: 10.3390/nu12113297. View

11.

Tang T, Hwang J, Yang T, Hsu C, Wu C, Liu T . Can Nutritional Intervention for Obesity and Comorbidities Slow Down Age-Related Hearing Impairment?. Nutrients. 2019; 11(7). PMC: 6682960. DOI: 10.3390/nu11071668. View

12.

Iwai H, Inaba M, Bui D, Suzuki K, Sakagami T, Yun Y . Treg and IL-1 receptor type 2-expressing CD4 T cell-deleted CD4 T cell fraction prevents the progression of age-related hearing loss in a mouse model. J Neuroimmunol. 2021; 357:577628. DOI: 10.1016/j.jneuroim.2021.577628. View

13.

Hederstierna C, Hultcrantz M, Collins A, Rosenhall U . Hearing in women at menopause. Prevalence of hearing loss, audiometric configuration and relation to hormone replacement therapy. Acta Otolaryngol. 2007; 127(2):149-55. DOI: 10.1080/00016480600794446. View

14.

Gates G, Mills J . Presbycusis. Lancet. 2005; 366(9491):1111-20. DOI: 10.1016/S0140-6736(05)67423-5. View

15.

Shin M, Pandya M, Espinosa K, Telang R, Boix J, Thorne P . Istradefylline Mitigates Age-Related Hearing Loss in C57BL/6J Mice. Int J Mol Sci. 2021; 22(15). PMC: 8348536. DOI: 10.3390/ijms22158000. View

16.

Guimaraes P, Frisina S, Mapes F, Tadros S, Frisina D, Frisina R . Progestin negatively affects hearing in aged women. Proc Natl Acad Sci U S A. 2006; 103(38):14246-9. PMC: 1560930. DOI: 10.1073/pnas.0606891103. View

17.

Lei D, Gao X, Perez P, Ohlemiller K, Chen C, Campbell K . Anti-epileptic drugs delay age-related loss of spiral ganglion neurons via T-type calcium channel. Hear Res. 2011; 278(1-2):106-12. PMC: 3152691. DOI: 10.1016/j.heares.2011.05.010. View

18.

Rousset F, Nacher-Soler G, Coelho M, Ilmjarv S, Beatrix Christina Kokje V, Marteyn A . Redox activation of excitatory pathways in auditory neurons as mechanism of age-related hearing loss. Redox Biol. 2020; 30:101434. PMC: 7016250. DOI: 10.1016/j.redox.2020.101434. View

19.

Mills J, Matthews L, Lee F, Dubno J, Schulte B, Weber P . Gender-specific effects of drugs on hearing levels of older persons. Ann N Y Acad Sci. 2000; 884:381-8. DOI: 10.1111/j.1749-6632.1999.tb08656.x. View

20.

Ren H, Chen J, Wang Y, Zhang S, Zhang B . Intracerebral neural stem cell transplantation improved the auditory of mice with presbycusis. Int J Clin Exp Pathol. 2013; 6(2):230-41. PMC: 3544227. View