Association of Serum and Hair Antioxidant Minerals with an Oxidative Stress Marker in Relation with Characteristics of Healthy Adults: a Cross-sectional Study

Overview

Journal Sci Rep

Specialty Science

Date 2024 Feb 9

PMID 38332317

Authors

Yoo-Ree Kang

Mi-Kyung Sung

Hyun-Wook Baik

Mi-Kyeong Choi

Affiliations

Soon will be listed here.

Abstract

Excess oxidative stress generated in the body causes various types of cellular damage, including DNA damage. Certain trace minerals act as antioxidants by functioning as cofactors for antioxidant enzymes. This study was conducted to evaluate the serum and hair concentrations of major antioxidant trace minerals (zinc, manganese, selenium, and chromium) and to determine the association between the oxidative stress marker urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and serum or hair antioxidant trace mineral concentrations, according to the general characteristics of healthy adults. Study participants were selected after screening, and 108 participants aged 19-69 years were finally included. Serum and hair trace mineral concentrations were analyzed using inductively coupled plasma mass spectrometry, and urine 8-OHdG levels were quantified using an ELISA kit. Results showed that urinary 8-OHdG levels were significantly higher in exercisers than in those who did not exercise. Correlation analysis revealed that urinary 8-OHdG was negatively correlated with hair zinc in participants over 60 years of age and with poor health status, and positively correlated with hair chromium in participants with irregular dietary habits. In conclusion, these results suggest that urinary 8-OHdG is particularly correlated with hair zinc and chromium levels. Additional large-scale epidemiological studies are needed to generally confirm these findings.

Citing Articles

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PMID: 39960618 DOI: 10.1007/s12011-025-04514-3.

References

Chen S, Jin X, Shan Z, Li S, Yin J, Sun T . Inverse Association of Plasma Chromium Levels with Newly Diagnosed Type 2 Diabetes: A Case-Control Study. Nutrients. 2017; 9(3). PMC: 5372957. DOI: 10.3390/nu9030294. View

Saito K, Aoki H, Fujiwara N, Goto M, Tomiyama C, Iwasa Y . Association of urinary 8-OHdG with lifestyle and body composition in elderly natural disaster victims living in emergency temporary housing. Environ Health Prev Med. 2012; 18(1):72-7. PMC: 3541811. DOI: 10.1007/s12199-012-0284-8. View

Robberecht H, De Bruyne T, Davioud-Charvet E, Mackrill J, Hermans N . Selenium Status in Elderly People: Longevity and Age-Related Diseases. Curr Pharm Des. 2019; 25(15):1694-1706. DOI: 10.2174/1381612825666190701144709. View

Graille M, Wild P, Sauvain J, Hemmendinger M, Guseva Canu I, Hopf N . Urinary 8-OHdG as a Biomarker for Oxidative Stress: A Systematic Literature Review and Meta-Analysis. Int J Mol Sci. 2020; 21(11). PMC: 7313038. DOI: 10.3390/ijms21113743. View

Chu A, Petocz P, Samman S . Immediate Effects of Aerobic Exercise on Plasma/Serum Zinc Levels: A Meta-analysis. Med Sci Sports Exerc. 2015; 48(4):726-33. DOI: 10.1249/MSS.0000000000000805. View

Gan W, Liu X, Yu T, Zou Y, Li T, Wang S . Urinary 8-oxo-7,8-dihydroguanosine as a Potential Biomarker of Aging. Front Aging Neurosci. 2018; 10:34. PMC: 5835306. DOI: 10.3389/fnagi.2018.00034. View

Tinkov A, Skalnaya M, Simashkova N, Klyushnik T, Skalnaya A, Bjorklund G . Association between catatonia and levels of hair and serum trace elements and minerals in autism spectrum disorder. Biomed Pharmacother. 2018; 109:174-180. DOI: 10.1016/j.biopha.2018.10.051. View

Gil F, Hernandez A, Marquez C, Femia P, Olmedo P, Lopez-Guarnido O . Biomonitorization of cadmium, chromium, manganese, nickel and lead in whole blood, urine, axillary hair and saliva in an occupationally exposed population. Sci Total Environ. 2011; 409(6):1172-80. DOI: 10.1016/j.scitotenv.2010.11.033. View

Ngala R, Awe M, Nsiah P . The effects of plasma chromium on lipid profile, glucose metabolism and cardiovascular risk in type 2 diabetes mellitus. A case - control study. PLoS One. 2018; 13(7):e0197977. PMC: 6033385. DOI: 10.1371/journal.pone.0197977. View

10.

Cardoso B, Hare D, Bush A, Roberts B . Glutathione peroxidase 4: a new player in neurodegeneration?. Mol Psychiatry. 2016; 22(3):328-335. DOI: 10.1038/mp.2016.196. View

11.

Cai Z, Zhang J, Li H . Selenium, aging and aging-related diseases. Aging Clin Exp Res. 2018; 31(8):1035-1047. DOI: 10.1007/s40520-018-1086-7. View

12.

Riales R, ALBRINK M . Effect of chromium chloride supplementation on glucose tolerance and serum lipids including high-density lipoprotein of adult men. Am J Clin Nutr. 1981; 34(12):2670-8. DOI: 10.1093/ajcn/34.12.2670. View

13.

Valavanidis A, Vlachogianni T, Fiotakis C . 8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009; 27(2):120-39. DOI: 10.1080/10590500902885684. View

14.

Pilger A, Rudiger H . 8-Hydroxy-2'-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures. Int Arch Occup Environ Health. 2006; 80(1):1-15. DOI: 10.1007/s00420-006-0106-7. View

15.

Cosentino G, Plantamura I, Cataldo A, Iorio M . MicroRNA and Oxidative Stress Interplay in the Context of Breast Cancer Pathogenesis. Int J Mol Sci. 2019; 20(20). PMC: 6829356. DOI: 10.3390/ijms20205143. View

16.

Bocca B, Madeddu R, Asara Y, Tolu P, Marchal J, Forte G . Assessment of reference ranges for blood Cu, Mn, Se and Zn in a selected Italian population. J Trace Elem Med Biol. 2011; 25(1):19-26. DOI: 10.1016/j.jtemb.2010.12.004. View

17.

Pieczynska J, Grajeta H . The role of selenium in human conception and pregnancy. J Trace Elem Med Biol. 2014; 29:31-8. DOI: 10.1016/j.jtemb.2014.07.003. View

18.

Amir Aslani B, Ghobadi S . Studies on oxidants and antioxidants with a brief glance at their relevance to the immune system. Life Sci. 2016; 146:163-73. DOI: 10.1016/j.lfs.2016.01.014. View

19.

Gorrini C, Harris I, Mak T . Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov. 2013; 12(12):931-47. DOI: 10.1038/nrd4002. View

20.

Srinivas U, Tan B, Vellayappan B, Jeyasekharan A . ROS and the DNA damage response in cancer. Redox Biol. 2019; 25:101084. PMC: 6859528. DOI: 10.1016/j.redox.2018.101084. View