The Mutographs Biorepository: A Unique Genomic Resource to Study Cancer Around the World

Large-scale biorepositories and databases are essential to generate equitable, effective, and sustainable advances in cancer prevention, early detection, cancer therapy, cancer care, and surveillance. The Mutographs project has created a large genomic dataset and biorepository of over 7,800 cancer cases from 30 countries across five continents with extensive demographic, lifestyle, environmental, and clinical information. Whole-genome sequencing is being finalized for over 4,000 cases, with the primary goal of understanding the causes of cancer at eight anatomic sites. Genomic, exposure, and clinical data will be publicly available through the International Cancer Genome Consortium Accelerating Research in Genomic Oncology platform. The Mutographs sample and metadata biorepository constitutes a legacy resource for new projects and collaborations aiming to increase our current research efforts in cancer genomic epidemiology globally.

Citing Articles

Geographic and age-related variations in mutational processes in colorectal cancer.

Diaz-Gay M, Dos Santos W, Moody S, Kazachkova M, Abbasi A, Steele C medRxiv. 2025; .

PMID: 40034755 PMC: 11875255. DOI: 10.1101/2025.02.13.25322219.

Colorectal Cancer: Current and Future Therapeutic Approaches and Related Technologies Addressing Multidrug Strategies Against Multiple Level Resistance Mechanisms.

Puzzo M, De Santo M, Morelli C, Leggio A, Catalano S, Pasqua L Int J Mol Sci. 2025; 26(3).

PMID: 39941081 PMC: 11818749. DOI: 10.3390/ijms26031313.

Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis.

Durfee C, Bergstrom E, Diaz-Gay M, Zhou Y, Temiz N, Ibrahim M bioRxiv. 2025; .

PMID: 39896515 PMC: 11785121. DOI: 10.1101/2025.01.18.633716.

Genomic landscape of cancer in racially and ethnically diverse populations.

Thomas C, Peters U Nat Rev Genet. 2024; .

PMID: 39609636 DOI: 10.1038/s41576-024-00796-w.

Methods and applications of genome-wide profiling of DNA damage and rare mutations.

Pfeifer G, Jin S Nat Rev Genet. 2024; 25(12):846-863.

PMID: 38918545 PMC: 11563917. DOI: 10.1038/s41576-024-00748-4.

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