Understanding of Spinal Wide Dynamic Range Neurons and Their Modulation on Pathological Pain

Overview

Journal J Pain Res

Publisher Dove Medical Press

Date 2024 Feb 6

PMID 38318328

Authors

Zhiyun Zhang

Hao Zheng

Qingquan Yu

Xianghong Jing

Affiliations

Soon will be listed here.

Abstract

The spinal dorsal horn (SDH) transmits sensory information from the periphery to the brain. Wide dynamic range (WDR) neurons within this relay site play a critical role in modulating and integrating peripheral sensory inputs, as well as the process of central sensitization during pathological pain. This group of spinal multi-receptive neurons has attracted considerable attention in pain research due to their capabilities for encoding the location and intensity of nociception. Meanwhile, transmission, processing, and modulation of incoming afferent information in WDR neurons also establish the underlying basis for investigating the integration of acupuncture and pain signals. This review aims to provide a comprehensive examination of the distinctive features of WDR neurons and their involvement in pain. Specifically, we will examine the regulation of diverse supraspinal nuclei on these neurons and analyze their potential in elucidating the mechanisms of acupuncture analgesia.

Citing Articles

Recent advances in acupuncture for pain relief.

Niruthisard S, Ma Q, Napadow V Pain Rep. 2024; 9(5):e1188.

PMID: 39285954 PMC: 11404884. DOI: 10.1097/PR9.0000000000001188.

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