: Botanical and Ethnopharmacological Insights, Phytochemical Investigations, and Prospects in Pharmacology and Pharmacotherapy

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Feb 6

PMID 38317880

Authors

Valentyna Opryshko

Anna Prokhach

Oleh Akimov

Mykola Riabushko

Heorhii Kostenko

Viktoriia Kostenko

Artur Mishchenko

Natalia Solovyova

Vitalii Kostenko

Affiliations

Soon will be listed here.

Abstract

The purpose of this inquiry is to provide a conprehensive summary and analysis of the literature concerning the pharmacological properties of components that can be extracted from , a preparation in Chinese medicine. This study also aims to explore their potential application in elaborating medicinal products for the effective prevention and treatment of such conditions as urolithiasis, cholelithiasis, type 2 diabetes mellitus, metabolic syndrome, pro-oxidant and inflammatory processes, etc. Several experimental studies confirmed the potential of to influence mineral metabolism, to decrease the concentration of constituents involved in the formation of urinary calculi, and to reduce mineral encrustation in the urinary tract, as well as to alleviate the damage caused by crystal structures. This beneficial impact is achieved through a combination of antioxidant and anti-inflammatory actions, along with urine alkalinization. The cholelitholytic, choleretic, and hepatoprotective effects of plants have been confirmed, primarily ascribed to the activation of the hepatic Xα receptor and the bile acid receptor, farnesoid X receptor, by the flavonoid shaftoside. Special attention is focused on the potential therapeutic applications of flavonoids derived from for diseases associated with the development of chronic inflammation and systemic response, emphasizing the ability of flavonoids to exert antioxidant and anti-inflammatory effects by acting directly and through the modulation of transcription factors. It is concluded that new strategies for the prevention and treatment of urolithiasis, cholelithiasis, type 2 diabetes mellitus, metabolic syndrome, acute and chronic inflammatory processes may rely on the promising development of dosage forms of with their subsequent preclinical and clinical trials.

Citing Articles

Therapeutic potential of 5-aminolevulinic acid in metabolic disorders: Current insights and future directions.

Kuryata O, Akimov O, Riabushko M, Kostenko H, Kostenko V, Mishchenko A iScience. 2024; 27(12):111477.

PMID: 39720526 PMC: 11667047. DOI: 10.1016/j.isci.2024.111477.

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