The Ratio of Cysteine-Rich Angiogenic Inducer 61 to MicroRNA -155 Expression As a Preeclampsia Diagnostic Marker and Predictor of Its Severity

Overview

Journal Rep Biochem Mol Biol

Specialty Biochemistry

Date 2024 Feb 6

PMID 38317812

Authors

Sarah Mamdouh Shoeib

Doaa Elwy Abdeldaim

Shaimaa Samir Mashal

Rowida Raafat Ibrahim

Lamees Mohamed Dawood

Doaa Shatat

Yasmine Ibrahim El-Masry

Ahmed Almeldin

Radwa Mahamoud El Sharaby

Affiliations

Soon will be listed here.

Abstract

Background: Preeclampsia (PE) is a multisystem pregnancy disorder that increases maternal-perinatal morbidity and mortality significantly. MicroRNA-155 (miR-155) overexpression in the sera of pregnant women has been linked to preeclampsia. Researchers discovered that miR-155 acts during pregnancy by down-regulating and reducing the cysteine-rich angiogenic inducer 61 (CYR61), which causes local ischemia as well as oxidative stress.

Methods: The level of miR-155 expression in all serum samples was quantified using real-time polymerase chain reaction (RT-PCR), and serum CYR61 was measured using enzyme-linked immunosorbent assays. Together with the Cyr-61/miR-155 ratio, they were evaluated as biomarkers for PE pathogenesis and severity prediction.

Results: MiR-155 expression, serum CYR61 levels, and Cyr-61/miR-155 ratios were all significantly higher in PE patients compared to the control group. Serum CYR61 levels and the Cyr-61/miR-155 ratio differed significantly between mild and severe PE patients.

Conclusions: MiR-155 expression, serum CYR61 levels, and Cyr-61/miR-155 may serve as biomarkers for PE pathogenesis and severity prediction.

Citing Articles

A Comparison of Apelin Rs56204867 and Apelin Receptor Rs11544374 Gene Polymorphisms and Their Association with Risk of Preeclampsia in Southeast Iran.

Juybar M, Shahraki M, Ghasemi M, Payandeh A, Saljooghi S, Saravani M Rep Biochem Mol Biol. 2025; 13(2):273-280.

PMID: 39995647 PMC: 11847591. DOI: 10.61186/rbmb.13.2.273.

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