New Targets for Type 2-low Asthma

Overview

Journal Korean J Intern Med

Specialty General Medicine

Date 2024 Feb 5

PMID 38317271

Authors

Quang Luu Quoc

Youngwoo Choi

Gyu-Young Hur

Hae-Sim Park

Affiliations

Soon will be listed here.

Abstract

Asthma is characterized by airway obstruction and inflammation, and presents significant diagnostic and treatment challenges. The concept of endotypes has improved understanding of the mechanisms of asthma and has stimulated the development of effective treatment strategies. Sputum profiles may be used to classify asthma into two major inflammatory types: type 2-high (T2H) and type 2-low (T2L) asthma. T2H, characterized by elevated type 2 inflammation, has been extensively studied and several effective biologic treatments have been developed. However, managing T2L is more difficult due to the lack of reliable biomarkers for accurate diagnosis and classification. Additionally, conventional anti-inflammatory therapy does not completely control the symptoms of T2L; therefore, further research is needed to identify effective biologic treatments. This review provides new insights into the clinical characteristics and underlying mechanisms of severe T2L and investigates potential therapeutic approaches to control the disease.

Citing Articles

Bioinformatics Analysis and Experimental Validation to Identify Key Glycosylation-Related Genes in Asthma.

Li Y, Wu R, Tian X, Zhang M, Cheng Z J Inflamm Res. 2024; 17:9469-9484.

PMID: 39606642 PMC: 11600937. DOI: 10.2147/JIR.S484542.

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