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Why is Early Detection of Colon Cancer Still Not Possible in 2023?

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Specialty Gastroenterology
Date 2024 Feb 5
PMID 38314134
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Abstract

Colorectal cancer (CRC) screening is a fundamental tool in the prevention and early detection of one of the most prevalent and lethal cancers. Over the years, screening, particularly in those settings where it is well organized, has succeeded in reducing the incidence of colon and rectal cancer and improving the prognosis related to them. Despite considerable advancements in screening technologies and strategies, the effectiveness of CRC screening programs remains less than optimal. This paper examined the multifaceted reasons behind the persistent lack of effectiveness in CRC screening initiatives. Through a critical analysis of current methodologies, technological limitations, patient-related factors, and systemic challenges, we elucidated the complex interplay that hampers the successful reduction of CRC morbidity and mortality rates. While acknowledging the advancements that have improved aspects of screening, we emphasized the necessity of addressing the identified barriers comprehensively. This study aimed to raise awareness of how important CRC screening is in reducing costs for this disease. Screening and early diagnosis are not only important in improving the prognosis of patients with CRC but can lead to an important reduction in the cost of treating a disease that is often diagnosed at an advanced stage. Spending more sooner can mean saving money later.

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References
1.
Maringe C, Spicer J, Morris M, Purushotham A, Nolte E, Sullivan R . The impact of the COVID-19 pandemic on cancer deaths due to delays in diagnosis in England, UK: a national, population-based, modelling study. Lancet Oncol. 2020; 21(8):1023-1034. PMC: 7417808. DOI: 10.1016/S1470-2045(20)30388-0. View

2.
Hasan M, Haider N, Stigler F, Khan R, McCoy D, Zumla A . The Global Case-Fatality Rate of COVID-19 Has Been Declining Since May 2020. Am J Trop Med Hyg. 2021; 104(6):2176-2184. PMC: 8176487. DOI: 10.4269/ajtmh.20-1496. View

3.
Ferrari A, Neefs I, Hoeck S, Peeters M, Van Hal G . Towards Novel Non-Invasive Colorectal Cancer Screening Methods: A Comprehensive Review. Cancers (Basel). 2021; 13(8). PMC: 8070308. DOI: 10.3390/cancers13081820. View

4.
Segnan N, Armaroli P, Bonelli L, Risio M, Sciallero S, Zappa M . Once-only sigmoidoscopy in colorectal cancer screening: follow-up findings of the Italian Randomized Controlled Trial--SCORE. J Natl Cancer Inst. 2011; 103(17):1310-22. DOI: 10.1093/jnci/djr284. View

5.
Pecere S, Senore C, Hassan C, Riggi E, Segnan N, Pennazio M . Accuracy of colon capsule endoscopy for advanced neoplasia. Gastrointest Endosc. 2019; 91(2):406-414.e1. DOI: 10.1016/j.gie.2019.09.041. View