Biofilm: Formulation, Regulatory, and Emerging Natural Products-derived Therapeutics

Overview

Journal Biofilm

Date 2024 Feb 1

PMID 38298832

Authors

Xiying Wu

Huan Wang

Juan Xiong

Guo-Xun Yang

Jin-Feng Hu

Quangang Zhu

Zhongjian Chen

Affiliations

Soon will be listed here.

Abstract

can readily form biofilm which enhances the drug-resistance, resulting in life-threatening infections involving different organs. Biofilm formation occurs due to a series of developmental events including bacterial adhesion, aggregation, biofilm maturation, and dispersion, which are controlled by multiple regulatory systems. Rapidly increasing research and development outcomes on natural products targeting biofilm formation and/or regulation led to an emergent application of active phytochemicals and combinations. This review aimed at providing an in-depth understanding of biofilm formation and regulation mechanisms for , outlining the most important antibiofilm strategies and potential targets of natural products, and summarizing the latest progress in combating biofilm with plant-derived natural products. These findings provided further evidence for novel antibiofilm drugs research and clinical therapies.

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