The Relationship Between Self-perceived Fatigue, Muscle Endurance, and Circulating Markers of Inflammation in Participants of the Copenhagen Aging and Midlife Biobank (CAMB)

Overview

Journal Eur Rev Aging Phys Act

Publisher Springer

Specialty Geriatrics

Date 2024 Jan 31

PMID 38297218

Authors

Ivan Bautmans

Veerle Knoop

Ingo Beyer

Helle Bruunsgaard

Drude Molbo

Erik Lykke Mortensen

Rikke Lund

Affiliations

Soon will be listed here.

Abstract

Background: Fatigue, low muscle endurance, muscle weakness and low-grade inflammation are strongly related to frailty at higher age. When signs of self-perceived fatigue and low muscle endurance are interrelated with low-grade inflammation at midlife, they might be used as early markers for frailty. This study investigated whether the interrelationships among self-perceived fatigue, muscle endurance and inflammation can be observed at midlife.

Methods: A total of 965 participants of the Copenhagen Aging and Midlife Biobank (aged 52 ± 4 years, 536 males, 426 females) were assessed for self-perceived fatigue (20-item multidimensional fatigue inventory), muscle endurance (grip work), circulating markers of inflammation (hsCRP, IL-6, IL-10, TNF-alpha and IFN-γ), daily physical activity (PAS-2), body composition (%body fat assessed by bio-impedance) and self-reported health status. Participants were categorised (correcting for age and gender) according to high fatigue and/or low muscle endurance, differences in inflammatory profile between fatigue categories were assessed by ANCOVA (corrected for PAS-2, %body fat and presence of inflammatory conditions).

Results: Overall, muscle endurance, fatigue and inflammatory markers were significantly interrelated. Higher levels of hsCRP (p < 0.001), IL-6 (p < 0.001), IL-10 (p = 0.035) and TNF-alpha (p = 0.028) were observed in participants presenting both low muscle endurance and high fatigue. IFN-γ was highest in those with high fatigue but normal muscle endurance (p = 0.015).

Conclusions: Middle-aged participants with higher fatigue in combination with low muscle endurance show higher levels of inflammation, independently from physical activity, body fat and inflammatory pathology. The underlying mechanisms should be identified and future studies should also investigate whether these individuals show early signs of reduced physiological reserve capacity, which in later life come to full expression by means of frailty.

Citing Articles

Feasibility of hand grip tests during and after hospitalization in geriatric patients: an observational study.

Swart M, Smetsers L, Bautmans I, da Silva H, Geerds M, Tielemans R BMC Geriatr. 2024; 24(1):703.

PMID: 39182024 PMC: 11344409. DOI: 10.1186/s12877-024-05305-6.

References

Cho H, Bower J, Kiefe C, Seeman T, Irwin M . Early life stress and inflammatory mechanisms of fatigue in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Brain Behav Immun. 2012; 26(6):859-65. PMC: 3398216. DOI: 10.1016/j.bbi.2012.04.005. View

Alvarez-Rodriguez L, Lopez-Hoyos M, Munoz-Cacho P, Martinez-Taboada V . Aging is associated with circulating cytokine dysregulation. Cell Immunol. 2012; 273(2):124-32. DOI: 10.1016/j.cellimm.2012.01.001. View

Bautmans I, Njemini R, Predom H, Lemper J, Mets T . Muscle endurance in elderly nursing home residents is related to fatigue perception, mobility, and circulating tumor necrosis factor-alpha, interleukin-6, and heat shock protein 70. J Am Geriatr Soc. 2008; 56(3):389-96. DOI: 10.1111/j.1532-5415.2007.01571.x. View

Hoekstra T, Barbosa-Leiker C, Twisk J . Vital exhaustion and markers of low-grade inflammation in healthy adults: the Amsterdam Growth and Health Longitudinal Study. Stress Health. 2013; 29(5):392-400. DOI: 10.1002/smi.2485. View

Fried L, Tangen C, Walston J, Newman A, Hirsch C, Gottdiener J . Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001; 56(3):M146-56. DOI: 10.1093/gerona/56.3.m146. View

Fried L, Cohen A, Xue Q, Walston J, Bandeen-Roche K, Varadhan R . The physical frailty syndrome as a transition from homeostatic symphony to cacophony. Nat Aging. 2021; 1(1):36-46. PMC: 8409463. DOI: 10.1038/s43587-020-00017-z. View

Morrisette-Thomas V, Cohen A, Fulop T, Riesco E, Legault V, Li Q . Inflamm-aging does not simply reflect increases in pro-inflammatory markers. Mech Ageing Dev. 2014; 139:49-57. PMC: 5881904. DOI: 10.1016/j.mad.2014.06.005. View

Manty M, Mendes de Leon C, Rantanen T, Era P, Pedersen A, Ekmann A . Mobility-related fatigue, walking speed, and muscle strength in older people. J Gerontol A Biol Sci Med Sci. 2011; 67(5):523-9. DOI: 10.1093/gerona/glr183. View

Enoka R, Duchateau J . Muscle fatigue: what, why and how it influences muscle function. J Physiol. 2007; 586(1):11-23. PMC: 2375565. DOI: 10.1113/jphysiol.2007.139477. View

10.

Felger J, Miller A . Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise. Front Neuroendocrinol. 2012; 33(3):315-27. PMC: 3484236. DOI: 10.1016/j.yfrne.2012.09.003. View

11.

Beyer I, Bautmans I, Njemini R, Demanet C, Bergmann P, Mets T . Effects on muscle performance of NSAID treatment with piroxicam versus placebo in geriatric patients with acute infection-induced inflammation. A double blind randomized controlled trial. BMC Musculoskelet Disord. 2012; 12:292. PMC: 3273447. DOI: 10.1186/1471-2474-12-292. View

12.

Bautmans I, Onyema O, Van Puyvelde K, Pleck S, Mets T . Grip work estimation during sustained maximal contraction: validity and relationship with dependency and inflammation in elderly persons. J Nutr Health Aging. 2011; 15(8):731-6. DOI: 10.1007/s12603-010-0317-1. View

13.

Lind A, Boraxbekk C, Petersen E, Paulson O, Siebner H, Marsman A . Regional Myo-Inositol, Creatine, and Choline Levels Are Higher at Older Age and Scale Negatively with Visuospatial Working Memory: A Cross-Sectional Proton MR Spectroscopy Study at 7 Tesla on Normal Cognitive Ageing. J Neurosci. 2020; 40(42):8149-8159. PMC: 7574655. DOI: 10.1523/JNEUROSCI.2883-19.2020. View

14.

Lind A, Boraxbekk C, Petersen E, Paulson O, Andersen O, Siebner H . Do glia provide the link between low-grade systemic inflammation and normal cognitive ageing? A H magnetic resonance spectroscopy study at 7 tesla. J Neurochem. 2021; 159(1):185-196. DOI: 10.1111/jnc.15456. View

15.

Solana R, Tarazona R, Aiello A, Akbar A, Appay V, Beswick M . CMV and Immunosenescence: from basics to clinics. Immun Ageing. 2012; 9(1):23. PMC: 3585851. DOI: 10.1186/1742-4933-9-23. View

16.

Minciullo P, Catalano A, Mandraffino G, Casciaro M, Crucitti A, Maltese G . Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity. Arch Immunol Ther Exp (Warsz). 2015; 64(2):111-26. DOI: 10.1007/s00005-015-0377-3. View

17.

Arnold P, Njemini R, Vantieghem S, Duchateau J, Mets T, Beyer I . Peripheral muscle fatigue in hospitalised geriatric patients is associated with circulating markers of inflammation. Exp Gerontol. 2017; 95:128-135. DOI: 10.1016/j.exger.2017.05.007. View

18.

Ronti T, Lupattelli G, Mannarino E . The endocrine function of adipose tissue: an update. Clin Endocrinol (Oxf). 2006; 64(4):355-65. DOI: 10.1111/j.1365-2265.2006.02474.x. View

19.

Knoop V, Costenoble A, Debain A, Vella Azzopardi R, Vermeiren S, Van Laere S . The interrelationship between grip work, self-perceived fatigue and pre-frailty in community-dwelling octogenarians. Exp Gerontol. 2021; 152:111440. DOI: 10.1016/j.exger.2021.111440. View

20.

Vermeiren S, Vella-Azzopardi R, Beckwee D, Habbig A, Scafoglieri A, Jansen B . Frailty and the Prediction of Negative Health Outcomes: A Meta-Analysis. J Am Med Dir Assoc. 2016; 17(12):1163.e1-1163.e17. DOI: 10.1016/j.jamda.2016.09.010. View