Circulating Extracellular Vesicles As a Potential Mediator of Synuclein Pathology in the Gut

Overview

Journal Mov Disord

Date 2024 Jan 31

PMID 38294044

Authors

Timothy R Sampson

Affiliations

Soon will be listed here.

Citing Articles

Trends and hotspots on the relationship between gut microbiota and Parkinson's Disease: a bibliometric analysis.

Li X, Hao X, Chen C, Zhai C, Pan T, Zhou X Front Cell Infect Microbiol. 2024; 14:1421270.

PMID: 39403202 PMC: 11472709. DOI: 10.3389/fcimb.2024.1421270.

References

Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour A, Toth M . The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med. 2014; 6(263):263ra158. PMC: 4396848. DOI: 10.1126/scitranslmed.3009759. View

Kim S, Kwon S, Kam T, Panicker N, Karuppagounder S, Lee S . Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease. Neuron. 2019; 103(4):627-641.e7. PMC: 6706297. DOI: 10.1016/j.neuron.2019.05.035. View

Tian C, Liu G, Gao L, Soltys D, Pan C, Stewart T . Erythrocytic α-Synuclein as a potential biomarker for Parkinson's disease. Transl Neurodegener. 2019; 8:15. PMC: 6521422. DOI: 10.1186/s40035-019-0155-y. View

Kaelberer M, Buchanan K, Klein M, Barth B, Montoya M, Shen X . A gut-brain neural circuit for nutrient sensory transduction. Science. 2018; 361(6408). PMC: 6417812. DOI: 10.1126/science.aat5236. View

Wallen Z, Demirkan A, Twa G, Cohen G, Dean M, Standaert D . Metagenomics of Parkinson's disease implicates the gut microbiome in multiple disease mechanisms. Nat Commun. 2022; 13(1):6958. PMC: 9663292. DOI: 10.1038/s41467-022-34667-x. View

Yang Y, Stewart T, Zhang C, Wang P, Xu Z, Jin J . Erythrocytic α-Synuclein and the Gut Microbiome: Kindling of the Gut-Brain Axis in Parkinson's Disease. Mov Disord. 2023; 39(1):40-52. DOI: 10.1002/mds.29620. View

Arotcarena M, Dovero S, Prigent A, Bourdenx M, Camus S, Porras G . Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates. Brain. 2020; 143(5):1462-1475. DOI: 10.1093/brain/awaa096. View

Liang F, Chen C, Li Y, Ke Y, Ho E, Jeng C . Early Dysbiosis and Dampened Gut Microbe Oscillation Precede Motor Dysfunction and Neuropathology in Animal Models of Parkinson's Disease. J Parkinsons Dis. 2022; 12(8):2423-2440. DOI: 10.3233/JPD-223431. View

Verbaan D, Marinus J, Visser M, van Rooden S, Stiggelbout A, van Hilten J . Patient-reported autonomic symptoms in Parkinson disease. Neurology. 2007; 69(4):333-41. DOI: 10.1212/01.wnl.0000266593.50534.e8. View

10.

Challis C, Hori A, Sampson T, Yoo B, Challis R, Hamilton A . Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice. Nat Neurosci. 2020; 23(3):327-336. PMC: 7065967. DOI: 10.1038/s41593-020-0589-7. View

11.

Chen S, Stribinskis V, Rane M, Demuth D, Gozal E, Roberts A . Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans. Sci Rep. 2016; 6:34477. PMC: 5052651. DOI: 10.1038/srep34477. View

12.

Horsager J, Andersen K, Knudsen K, Skjaerbaek C, Fedorova T, Okkels N . Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study. Brain. 2020; 143(10):3077-3088. DOI: 10.1093/brain/awaa238. View

13.

Borghammer P, Van Den Berge N . Brain-First versus Gut-First Parkinson's Disease: A Hypothesis. J Parkinsons Dis. 2019; 9(s2):S281-S295. PMC: 6839496. DOI: 10.3233/JPD-191721. View

14.

Siderowf A, Concha-Marambio L, Lafontant D, Farris C, Ma Y, Urenia P . Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study. Lancet Neurol. 2023; 22(5):407-417. PMC: 10627170. DOI: 10.1016/S1474-4422(23)00109-6. View

15.

Jucker M, Walker L . Self-propagation of pathogenic protein aggregates in neurodegenerative diseases. Nature. 2013; 501(7465):45-51. PMC: 3963807. DOI: 10.1038/nature12481. View

16.

Holmqvist S, Chutna O, Bousset L, Aldrin-Kirk P, Li W, Bjorklund T . Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats. Acta Neuropathol. 2014; 128(6):805-20. DOI: 10.1007/s00401-014-1343-6. View

17.

Manfredsson F, Luk K, Benskey M, Gezer A, Garcia J, Kuhn N . Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology. Neurobiol Dis. 2018; 112:106-118. PMC: 5890443. DOI: 10.1016/j.nbd.2018.01.008. View

18.

Fang P, Kazmi S, Jameson K, Hsiao E . The Microbiome as a Modifier of Neurodegenerative Disease Risk. Cell Host Microbe. 2020; 28(2):201-222. PMC: 7430034. DOI: 10.1016/j.chom.2020.06.008. View

19.

Braak H, Rub U, Gai W, Del Tredici K . Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. J Neural Transm (Vienna). 2003; 110(5):517-36. DOI: 10.1007/s00702-002-0808-2. View

20.

Chandra R, Hiniker A, Kuo Y, Nussbaum R, Liddle R . α-Synuclein in gut endocrine cells and its implications for Parkinson's disease. JCI Insight. 2017; 2(12). PMC: 5470880. DOI: 10.1172/jci.insight.92295. View