Synthesis, Crystal Structure, Thermal Stability and Biological Study of Bis{(2-methoxy-6-[(E)-(propylimino)methyl]phenolato}nickel(II) Complex

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Jan 31

PMID 38293524

Authors

S Sindhu

S Arockiasamy

Affiliations

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Abstract

A Schiff base complex of nickel, bis{(2-methoxy-6-[(E)-(propylimino)methyl]phenolato}nickel(II) was synthesised by condensing bis(2-hydroxy-3-methoxybenzaldehyde) nickel (II) and n-propylamine in methanolic medium. Single crystal X-ray diffraction analysis of the complex revealed it to possess planar geometry with a monoclinic crystal system. The non-isothermal TG/DTA runs on this complex in a high purity (99.99 %) nitrogen environment at atmospheric pressure confirmed the absence of any coordinated water. A sharp endotherm in its DTA shows a melting temperature range of 168-171 °C. It is thermally stable up to 243 °C and decomposes in two steps, yielding NiO and carbon as residue. In addition to the methoxy group (-OCH), infrared analysis (IR) confirmed the presence of the characteristic azomethine group (-C[bond, double bond]N-) which is also responsible for the biological action. It was further analysed by elemental analyser (C, H, N), H and C NMR as well as mass spectrometry. It showed considerable antibacterial activity towards and when the concentration exceeds 200 μg/ml. The antifungal study shows significant inhibition with the antifungal drug imidazole as a positive control (PC). Small values of MIC, MBC/MIC indicate a lesser quantity of complex is required to inhibit the growth of micro-organisms.

Citing Articles

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