Critical Importance of Patient-reported Outcomes for a Comprehensive Assessment of Psoriatic Arthritis Patients

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2024 Jan 31

PMID 38293304

Authors

Marika Lo Monaco

Raffaella Mallaci Bocchio

Giuseppe Natoli

Annarita Giardina

Ignazio Cangemi

Salvatore Scibetta

Christiano Argano

Salvatore Corrao

Affiliations

Soon will be listed here.

Abstract

Introduction: Psoriatic arthritis (PsA) is a heterogeneous, chronic inflammatory disease that negatively impacts patients' quality of life. Patient-reported outcome measures (PROMs) are used to capture patient perspectives in disease assessment, and physicians use the Disease Activity Index for Psoriatic Arthritis (DAPSA) to evaluate disease activity in PsA. The study aimed to assess the relationship between PROMs and the DAPSA score in consecutive outpatients affected by PsA.

Materials And Methods: A cross-sectional study was conducted from March 2018 to October 2020 at the PsA clinic of the ARNAS Civico in Palermo (Italy), enrolling outpatients with PsA. Patients were assessed for their disease activity according to the DAPSA score, and PROMs, such as PHQ-9, HAQ, FACIT-F, and PsAID, were evaluated. Linear regression analysis evaluated the relationship between the DAPSA Score and the included PROMs.

Results: 158 PsA consecutive peripheral subset psoriatic arthritis outpatients were recruited. The median years of illness was 10.6 (9.3-11.9), and the median DAPSA score was 19.02 (9-33.1). The regression analysis highlighted a strong relationship between the DAPSA score and the PsAID (adjR 26%, < 0.0001), the FACIT-F (adjR 25.4%, p < 0.0001), the HAQ (adjR 23.7%, < 0.0001), and PHQ-9 (adjR 15%, < 0.0001).

Conclusion: PROMs are strongly associated with the DAPSA score, but it allows in-depth evaluation of the impact of the disease on different domains of PsA patients' life.

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