The Association Between S100A12 Protein and C-Reactive Protein with Malignant Ventricular Arrhythmias Following Acute Myocardial Infarction in the Elderly

Overview

Journal J Inflamm Res

Publisher Dove Medical Press

Date 2024 Jan 30

PMID 38288422

Authors

Lei Song

Ying-Min Lu

Jin-Chun Zhang

Yu-Min Yuan

Gui-Ru Li

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the association of S100A12 protein and C-reactive protein (CRP) with the onset of malignant ventricular arrhythmias (MVA) after acute myocardial infarction (AMI) in the elderly.

Methods: A total of 159 elderly AMI patients admitted to Chongming Hospital affiliated to Shanghai University of Medicine & Health Sciences from January 2018 to January 2023 were enrolled in the study. CRP levels were determined using an automatic biochemical analyzer, and S100A12 levels were measured using enzyme-linked immunosorbent assay (ELISA). Patients were categorized based on the Lown classification into groups without MVA and with MVA. Univariate analysis was initially performed to identify independent variables, followed by multivariate logistic regression to determine the risk factors for malignant ventricular arrhythmias post-AMI. The predictive value of S100A12 protein and CRP for malignant ventricular arrhythmias after acute myocardial infarction in the elderly was analyzed using the receiver operating characteristic (ROC) curve.

Results: Among the 159 patients with AMI, 27 (17%) had MVA. Multivariate logistic regression analysis indicated that both S100A12 protein and CRP could be independent risk factors for malignant ventricular arrhythmias following acute myocardial infarction in the elderly ( 0.05). The area under the ROC curve showed the area under the curve (AUC) for S100A12 protein to be 0.7147, for CRP 0.7356, and for the combined diagnosis 0.8350 ( 0.05).

Conclusion: S100A12 protein and CRP are independent risk factors for MVA after MI in the elderly. The combined application of S100A12 protein and CRP has higher diagnostic sensitivity and specificity.

References

Citaku H, Miftari R, Stubljar D, Krasniqi X . Size of Acute Myocardial Infarction Correlates with Earlier Time of Initiation of Reperfusion Therapy with Cardiac Perfusion Scintigraphy: A National Single-Center Study. Med Sci Monit Basic Res. 2021; 27:e933214. PMC: 8447851. View

Singh H, Rai V, Agrawal D . LPS and oxLDL-induced S100A12 and RAGE expression in carotid arteries of atherosclerotic Yucatan microswine. Mol Biol Rep. 2022; 49(9):8663-8672. DOI: 10.1007/s11033-022-07703-8. View

Xie J, Noeman M, Pimenta D, Little C . C-reactive protein as a predictor for developing post-operative atrial fibrillation. Europace. 2020; 23(1):159. DOI: 10.1093/europace/euaa303. View

Zhou Z, Liu C, Xu S, Wang J, Guo F, Duan S . Metabolism regulator adiponectin prevents cardiac remodeling and ventricular arrhythmias via sympathetic modulation in a myocardial infarction model. Basic Res Cardiol. 2022; 117(1):34. DOI: 10.1007/s00395-022-00939-2. View

Zhang N, Shi F, Liang H, Wang H . The feasibility of using Hcy, CRP, and Cys-C to analyze AMI patients' disease conditions and prognoses. Am J Transl Res. 2021; 13(4):2724-2730. PMC: 8129397. View

Bagci A, Aksoy F . Systemic immune-inflammation index predicts new-onset atrial fibrillation after ST elevation myocardial infarction. Biomark Med. 2021; 15(10):731-739. DOI: 10.2217/bmm-2020-0838. View

Sun W, Wu Y, Gao M, Tian Y, Qi P, Shen Y . C-reactive protein promotes inflammation through TLR4/NF-κB/TGF-β pathway in HL-1 cells. Biosci Rep. 2019; 39(8). PMC: 6712437. DOI: 10.1042/BSR20190888. View

Nurmohamed N, Belo Pereira J, Hoogeveen R, Kroon J, Kraaijenhof J, Waissi F . Targeted proteomics improves cardiovascular risk prediction in secondary prevention. Eur Heart J. 2022; 43(16):1569-1577. PMC: 9020984. DOI: 10.1093/eurheartj/ehac055. View

Zeymer U . [Diagnosis and initial management of acute myocardial infarction]. MMW Fortschr Med. 2019; 161(4):34-36. DOI: 10.1007/s15006-019-0223-3. View

10.

Takada T, Shishido K, Hayashi T, Yokota S, Miyashita H, Yokoyama H . Impact of Late Ventricular Arrhythmias on Cardiac Mortality in Patients with Acute Myocardial Infarction. J Interv Cardiol. 2019; 2019:5345178. PMC: 6739782. DOI: 10.1155/2019/5345178. View

11.

Wang C, Qin X, Nie S, Wang C, Ai H, Que B . C-reactive protein as a predictor of malignant ventricular arrhythmias in non-ST elevation myocardial infarction. J Geriatr Cardiol. 2019; 16(8):614-620. PMC: 6748903. DOI: 10.11909/j.issn.1671-5411.2019.08.007. View

12.

Sheriff A, Kayser S, Brunner P, Vogt B . C-Reactive Protein Triggers Cell Death in Ischemic Cells. Front Immunol. 2021; 12:630430. PMC: 7934421. DOI: 10.3389/fimmu.2021.630430. View

13.

Wang L, Peng Y, Song L, Xia D, Li C, Li Z . Colchicine-Containing Nanoparticles Attenuates Acute Myocardial Infarction Injury by Inhibiting Inflammation. Cardiovasc Drugs Ther. 2021; 36(6):1075-1089. DOI: 10.1007/s10557-021-07239-2. View

14.

Chung M, Martin D, Sprecher D, Wazni O, Kanderian A, Carnes C . C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation. Circulation. 2001; 104(24):2886-91. DOI: 10.1161/hc4901.101760. View

15.

Wu W, He J, Zhang S, Zeng C, Wang Q . Basic demographic characteristics and prevalence of comorbidities in acute mesenteric ischemia: a systematic review and proportional meta-analysis. Scand J Gastroenterol. 2022; 58(6):605-618. DOI: 10.1080/00365521.2022.2152289. View

16.

Wang Z, Wang B, Li X, Zhang S, Wu S, Xia Y . Metabolic syndrome, high-sensitivity C-reactive protein levels and the risk of new-onset atrial fibrillation: Results from the Kailuan Study. Nutr Metab Cardiovasc Dis. 2021; 31(1):102-109. DOI: 10.1016/j.numecd.2020.06.026. View

17.

Maier W, Altwegg L, Corti R, Gay S, Hersberger M, Maly F . Inflammatory markers at the site of ruptured plaque in acute myocardial infarction: locally increased interleukin-6 and serum amyloid A but decreased C-reactive protein. Circulation. 2005; 111(11):1355-61. DOI: 10.1161/01.CIR.0000158479.58589.0A. View

18.

Kim K, Kim H, Binas B, Kang J, Chung I . Inflammatory mediators ATP and S100A12 activate the NLRP3 inflammasome to induce MUC5AC production in airway epithelial cells. Biochem Biophys Res Commun. 2018; 503(2):657-664. DOI: 10.1016/j.bbrc.2018.06.057. View

19.

Stengaard C, Sorensen J, Rasmussen M, Botker M, Pedersen C, Terkelsen C . Prehospital diagnosis of patients with acute myocardial infarction. Diagnosis (Berl). 2018; 3(4):155-166. DOI: 10.1515/dx-2016-0021. View

20.

Alkouri A, Cybularz M, Mierke J, Nowack T, Biedermann J, Ulbrich S . The predictive role of early CRP values for one-year mortality in the first 2 d after acute myocardial infarction. Biomarkers. 2022; 27(3):293-298. DOI: 10.1080/1354750X.2022.2040591. View