Exploring the Promising Role of Guggulipid in Rheumatoid Arthritis Management: An In-depth Analysis

Overview

Journal Curr Rheumatol Rev

Publisher Bentham Science Publishers

Specialty Rheumatology

Date 2024 Jan 29

PMID 38284718

Authors

Amit Sahu

Sunny Rathee

Sanjay Kumar Jain

Umesh Kumar Patil

Affiliations

Soon will be listed here.

Abstract

Background: Guggulipid, an oleo-gum resin extracted from the bark of of the Burseraceae family, holds a significant place in Ayurvedic medicine due to its historical use in treating various disorders, including inflammation, gout, rheumatism, obesity, and lipid metabolism imbalances.

Objective: This comprehensive review aims to elucidate the molecular targets of guggulipids and explore their cellular responses. Furthermore, it summarizes the findings from , and clinical investigations related to arthritis and various inflammatory conditions.

Methods: A comprehensive survey encompassing , and clinical studies has been conducted to explore the therapeutic capacity of guggulipid in the management of rheumatoid arthritis. Various molecular pathways, such as cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), PI3-kinase/AKT, JAK/STAT, nitric oxide synthase (iNOS), and NFκB signaling pathways, have been targeted to assess the antiarthritic and anti-inflammatory effects of this compound.

Results: The research findings reveal that guggulipid demonstrates notable antiarthritic and anti-inflammatory effects by targeting key molecular pathways involved in inflammatory responses. These pathways include COX-2, VEGF, PI3-kinase/AKT, JAK/STAT, iNOS, and NFκB signaling pathways. , and clinical studies collectively support the therapeutic potential of guggulipid in managing rheumatoid arthritis and related inflammatory conditions.

Conclusion: This review provides a deeper understanding of the therapeutic mechanisms and potential of guggulipid in the management of rheumatoid arthritis. The collective evidence strongly supports the promising role of guggulipid as a therapeutic agent, encouraging further research and development in guggulipid-based treatments for these conditions.

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