Leukemia and Mitophagy: a Novel Perspective for Understanding Oncogenesis and Resistance

Overview

Journal Ann Hematol

Specialty Hematology

Date 2024 Jan 28

PMID 38282059

Authors

Yueyao Liu

Zhigui Ma

Affiliations

Soon will be listed here.

Abstract

Mitophagy, the selective autophagic process that specifically degrades mitochondria, serves as a vital regulatory mechanism for eliminating damaged mitochondria and maintaining cellular balance. Emerging research underscores the central role of mitophagy in the initiation, advancement, and treatment of cancer. Mitophagy is widely acknowledged to govern mitochondrial homeostasis in hematopoietic stem cells (HSCs), influencing their metabolic dynamics. In this article, we integrate recent data to elucidate the regulatory mechanisms governing mitophagy and its intricate significance in the context of leukemia. An in-depth molecular elucidation of the processes governing mitophagy may serve as a basis for the development of pioneering approaches in targeted therapeutic interventions.

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